CYTOKINES — Interleukins, CSF, TNF, IFN, & Others

Question 1

Interleukin 1a

Answer 1

Macrophages
Monocytes
Endothelial Cells

—

Acts on the hypothalamus to cause fever
Proliferation of activated B and T cells

Question 2

Interleukin 1b

Answer 2

Fibroblasts
Epithelial Cells

—

Acts on the hypothalamus to cause fever
Proliferation of B and T cells

Question 3

Interleukin 2

Answer 3

T Cells

—

Proliferation of activated T and B cells
Stimulation of Lymphokine-activated killer (LAK) cells
Cytotoxicity of NK cells

Question 4

Interleukin 3

Answer 4

T cells

—

Differentiation of hematopoietic stem cells, mast cells

Question 5

Interleukin 4

Answer 5

CD4+ cells
Bone marrow stroma

—

B cell growth factor I
Growth factor for:
- T cells
- Mast Cells
- Macrophages
- Proliferation of B cells
- Class Switching B cells

Question 6

Interleukin 5

Answer 6

CD4+ T cells
Mast cells

—

B cell growth factor II
B cell differentiating factor
Proliferation of:
- Activated B cells
- Eosinophils

Question 7

Interleukin 6

Answer 7

CD4+ Cells
Macrophages
Fibroblasts

—

Differentiation of B cells, hematopoietic precursors
Induction of acute-phase proteins
Stimulates B cells to plasma cells; antibody production

Question 8

Interleukin 7

Answer 8

Bone Marrow — Stromal cells

—

Proliferation of:
- Pre-B
- Pre-T
- Activated mature T cells

Question 9

Interleukin 8

Answer 9

Monocytes
Macrophages

—

Chemotaxis
Activation of neutrophils: chemotactic for T cells

Question 10

Interleukin 9

Answer 10

CD4+ T cells

—

Growth of activated CD4+ cells
Proliferation of mast cells

Question 11

Interleukin 10

Answer 11

T cells
Macrophages

—

Potent suppressor of macrophage functions

Question 12

Interleukin 11

Answer 12

Bone marrow — stromal cells

—

Induction of acute phase reactants

Question 13

Interleukin 12

Answer 13

T cells

—

Activates NK cells

Question 14

Interleukin 13

Answer 14

T cells

—

Inhibits the release of inflammatory cytokines

Question 15

Interleukin 14

Answer 15

T cells

—

Induces proliferation of activated B cells

Question 16

GM-CSF

Answer 16

T cells
Macrophage
Fibroblast
Mast cells
Endothelium

—

Growth of granulocyte and macrophage colonies
Activated MEN (macrophages, eosinophils, and neutrophils)

Question 17

G-CSF

Answer 17

Fibroblasts
Endothelium

—

Growth of mature granulocytes

Question 18

M-CSF

Answer 18

Fibroblasts
Endothelium
Epithelium

—

Growth of macrophage colonies

Question 19

Steel Factor

Answer 19

Bone Marrow — Stromal cells

—
Stem cell division (c-kit ligand)

Question 20

TNF

Answer 20

Macrophages

—

Tumor cytotoxicity; cachexia
Antiviral (IFN-like) and antiparasitic activity
Activation of phagocytic cells
Induction of IFN-y, IL-1, GM-CSF, and IL-6
Endogenous pyrogen to induce fever; induction of APR

Question 21

TNF-a

Answer 21

Macrophages
NK cells

—

Cachetin
Local inflammation
Acute phase proteins

Question 22

TNF-b

Answer 22

T cells (CD4 & CD8)
B cells

—

Lymphotoxin
Killing of target cells

Question 23

Interferon-a

Answer 23

Leukocytes

—

Antiviral
Increased MCH Class I expression

Question 24

Interferon-B

Answer 24

Leukocytes

—

Antiviral
Increased MCH Class I expression

Question 25

Interferon-y

Answer 25

T cells
NK cells

—

Antiviral; macrophage activation
Expression of MHC Class I & II on macrophages and other cells
Antagonism on several IL-4 actions

Question 26

TGF-B

Answer 26

T cells
Macrophages

—

Inhibits:
- Proliferation of T cells
- Activation of macrophages

Inhibitis: via TGF-B1
- IL-3
CSF-induced hematopoiesis

Wound repair and angiogenesis

Question 27

LIF

Answer 27

T cells

—

Inhibits proliferation of embryonic stem cells without affectng differentiation
Chemoattraction and activation of eosinophils