Cytokines etc

Question 1

IL-1

Answer 1

Secreted by: Macrophages
Action: ↑ expression of adhesion proteins (CAM and E-selectin) on endothelial cells
Special:

Question 2

IL-2

Answer 2

Secreted by: T cells
Action: T cell growth fatctor
Special:

Question 3

IL-3

Answer 3

Secreted by: T cells
Action: ↑HSC differentiation
Special:

Question 4

IL-4

Answer 4

Secreted by: Th2
Action: Class switching to E
Special:

Question 5

IL-5

Answer 5

Secreted by: Th2
Action: Class switching to A; eosinophil chemotaxis/activation
Special:

Question 6

IL-6

Answer 6

Secreted by: Macrophages
Action: production of acute phase reactants; fever
Special:

Question 7

IL-8

Answer 7

Secreted by: Macrophages
Action: Neutrophil chemotaxis
Special:

Question 8

IL-10

Answer 8

Secreted by: Th2
Action: at-TEN-uates immune response via ↓ MHC II expression and ↓ Th1 cytokines
Special:

Question 9

IL-12

Answer 9

Secreted by: Macrophages
Action: Th1 differentiation and NK activation (KILL!)
Special:

Question 10

IFN-α and IFN-β

Answer 10

Secreted by: cells
Action: induces apoptosis for protection against viruses
Special:
IFN-α used to treat Hep B/C, Hairy Cell L., and Kaposi Sarcoma
IFN-β used to treat MS

Question 11

IFN-γ

Answer 11

Secreted by: Th1 and NK’s
Action: stimulates macrophages to KILL!
Special:

Question 12

Prostaglandins (PGD2, PGE2, PGI2, PGF2)

Answer 12

Secreted by: cells via COX
Action: vasodilation (arteriole) and ↑vascular permeability (venule)
Special: E2 mediates pain + fever; I2 inhibits PLT aggregation

Question 13

LTB4

Answer 13

Secreted by: cells via lipoxygenase
Action: neutrophil chemotaxis
Special:

Question 14

Leukotrienes (LTC4, LTD4, LTE4)

Answer 14

Secreted by: cells via lipoxygenase
Action: smooth muscle contraction effects (aka permeability, vasoconstriction, and bronchoconstriction)
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Question 15

TNF-α

Answer 15

Secreted by: macrophages
Action: induces and maintains granuloma formation
Special: