Cytokines Flashcards
IL-1
Osteoclast activating factor
Causes fever, inflammation
Activates endothelium to express adhesion molecules
Induces cytokine secretion to recruit WBC
IL-6
Acute phase protein secretion and fever
IL-8
Neutrophilic chemotactic factor
IL-12
Activate TH1
Activate NK cells
TNFa
Mediates septic shock Activates endothelium causes WBC recruitment vascular leak ** mediates cachexia in malignancy
Secreted by T cells
IL-2, IL-3
IL-2
proliferation of all lines of T cell
Proliferation of NK cells
IL-3
Acts like G-CSF: bone marrow prolifereation and differentiation
Secreted by TH1 cells
IFNg Stimulates macrophages Also activates NK cells Inc. expression and antigen presentation on all cells (accts via the JAK-stat pathway)
From TH2 cells
IL-1, IL-5, IL-10
IL-4
beg 4 it
- mediations proliferation of B cells
- Class switching to IgE and IgG
- TH2 stimulation
IL-5
Class switching it IgA
Differentiation and prolifeation of eosinophils
IL-10
Modulates the inflammatory response
Dec. the expression of MCH2 and TH1 cytokines
Inhibits activated macrophages and dendritic cells
Secreted by regulatory cells along with TGF-B
Secreted by Macrophages
IL-1, IL-6, IL-8, IL-12, TNFa
