Autoantibodies

Question 1

Anti-basement membrane

Answer 1

Goodpasture syndrome

Question 2

Anticardiolipin, lupus anticoagulant

Answer 2

SLE, antiphospholipid syndrome

Question 3

Anticentromere

Answer 3

CREST scleroderma

Question 4

Anti-desmosome (anti-desmoglein)

Answer 4

Pemphigus Vulgaris

Question 5

Anti-dsDNA, anti-Smith

Answer 5

SLE

Question 6

Anti-glutamic acid decarboxylase

Answer 6

DM type 1

Question 7

Antihemidesmosome

Answer 7

Bullous pemphigoid

Question 8

Anti-histone

Answer 8

Drug induced lupus

Question 9

Anti-Jo-1, anti-SRP, anti-Mi-2

Answer 9

Polymyositis, dermatomyositis

Question 10

Antimicrosomal, antithyroglobulin

Answer 10

Hashimoto thyroiditis

Question 11

Antimitochondrial

Answer 11

Primary biliary cirrhosis

Question 12

Antinuclear antibodies

Answer 12

SLE, nonspecific

Question 13

Antiparietal cell

Answer 13

Pernicious anemia

Question 14

Anti-Scl-70 (anti-DNA topoisomerase I)

Answer 14

Diffuse Scleroderma

Question 15

Anti-smooth muscle

Answer 15

Autoimmune hepatitis

Question 16

Anti-SSA, Anti-SSB (anti-Ro, anti-La)

Answer 16

Sjogren syndrome

Question 17

Anti-TSH receptor

Answer 17

Graves

Question 18

Anti-U1 RNP (ribonucleoprotein)

Answer 18

Mixed connective tissue disease

Question 19

IgA anti-endomysial, IgA anti-tissue transglutaminase

Answer 19

Celiac disease

Question 20

MPO-ANCA/p-ANCA

Answer 20

Micoscopic polyangiitis, eosinophilic granulomatosis with polyangiitis (Churg-Strauss), Pauci-immune crescentic glomerulonephritis

Question 21

PR3-ANCA/c-ANCA

Answer 21

Granulomatosis with polyangiitis (Wegener)

Question 22

Rheumatoid factor, anti-CCP

Answer 22

Rheumatoid arthritis, Rheumatoid factor is IgM that targtes IgG Fc region, anti-CCP is more specific

Question 23

Anti-ACh receptor

Answer 23

Myasthenia Gravis