Cytokines

Question 1

IL-1

Answer 1

Producers: macrophages, B cells, NK cells (other somatic cells)
Targets: T cells, B cells, macrophages, endothelium
Effects: Lymphocyte activation, macrophage stimulation, endothelium adhesion, fever, acute phase proteins

Question 2

IL-2

Answer 2

Producers: T cells
Targets: T cells & NK cells
Effects: T cell and NK activation and proliferation

Question 3

IL-4

Answer 3

Producers: T cells, Th2 cells, mast cells
Targets: B cells, T cells
Effects: B cell growth factor, isotype switching to IgE, Th2 differentiation and Th1 supression

Question 4

IL-5

Answer 4

Producers: T cells, Th2 cells, mast cells
Targets: B cells
Effects: B cell GF, isotype switching to IgA, eosinophil growth

Question 5

IL-6

Answer 5

Producers: T & B cells, macrophages (other somatic cells too)
Targets: T, B cells, macrophages
Effects: acute phase response, Th17 differentiation, proliferation of antibody producing cells

Question 6

IL-10

Answer 6

Producers: T cells, Th2 cells
Targets: Th1 cells
Effects: inhibition of cytokine production and macrophage function

Question 7

IL-12

Answer 7

Producers: monocytes, APCs
Targets: Th1 cells, NK cells
Effects: differentiation of Th1 cells, NK activation

Question 8

TNF-alpha

Answer 8

Producers: lymphocytes, macrophages, mast cells
Targets: many cells
Effects: proinflammatory, endothelial activation, shock, acute phase proteins, PMN activation

Question 9

TNF-beta

Answer 9

Producers: T cells, monocytes (most cells too)
Targets: most cells
Effects: inhibits cell activation, anti-inflammatory, promotes IgA secretion

Question 10

INF-a/b

Answer 10

Producers: most cells
Targets: most cells
Effects: antiviral, increased MHC I expression

Question 11

INF-y

Answer 11

Producers: NK cells, T cells
Targets: B cells, macrophages, DC, endothelial
Effects: increased MHC II expression, macrophage activation, IgG class switching, suppression of Th2 cells