CD antigens

Question 1

CD3

Answer 1

Expressed in: T cells

Function: associates with TCR, mediates TCR signalling

Question 2

CD4

Answer 2

Expressed in: T helper cells, cells expressing MHCII

Function: assits MHC II in activating T cells

Question 3

CD8

Answer 3

Expressed in: CTL, T cells that react to MHC I

Function: binds to MHC I and assists in activating reactive T cells

Question 4

CD28

Answer 4

Expressed in: T cells

Function: Costimulation- binds to CD80 and CD86

Question 5

CD40

Answer 5

Expressed in: B cells, macrophages, DCs

Function: activates B cells, macrophages and CD with CD154

Question 6

CD80 (aka B7, B7-1)

Answer 6

Expressed in: B cells, macrophages and DCs

Function: Binds to CD28 and CTLA-4, costimulation for T cell activation

Question 7

CD86 (aka B7-2)

Answer 7

Expressed in: B cells, macrophages, DCs

Function: Binds to CD28 and CTLA-4, costimulation for T cell activation (like CD80)

Question 8

CD95 (aka Fas, APO-1)

Answer 8

Expressed in: activated T and B cells, monocytes

Function: induces apoptosis upon interaction with CD178

Question 9

CD154 (aka CD40 ligand, CD40L)

Answer 9

Expressed in: Activated CD4 T cells

Function: binds to CD40, activates B cells, macrophages, DCs

Question 10

CD178 (Fas ligand)

Answer 10

Expressed in: T cells and NK cells (induced)

Function: Binds to Fas and induces apoptosis of Fas+ cells to downregulate immune response

Question 11

CCR7

Answer 11

Activates integrins and chemotaxis

Question 12

CD-25

Answer 12

T cell receptor for IL-2