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Immunology > Cytokine Review Table > Flashcards

Cytokine Review Table Flashcards

1
Q

Function: IL17

A
  • Activate / Mitogen for PMNs
  • Increase antimicrobial peptides
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2
Q

Function: IL8 & other chemokines

A
  • PMN chemotaxis
  • Leukocyte migration
  • Dendritic cell lymph node migration
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2
Q

Target: IFNβ

A

All cells

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2
Q

Target: IL18

A

NK cells

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3
Q

Target: IL4

A

B cells

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4
Q

Source: G-CSF

A

macrophages, T cells

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5
Q

Function: IL6

A
  • Acute phase protein synthesis
  • Proliferation of antibody producing B cells
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5
Q

Target: IFNγ

A

macrophage, B cell

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6
Q

Source: TNF

A

macrophage, T cells

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7
Q

Target: IL5

A

B cell

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8
Q

Source: IFNγ

A

Th1 T cells

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9
Q

Source: IL15

A

macrophages

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10
Q

Function: IL18

A
  • Mitogen for NK cells
  • IFNγ production
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11
Q

Source: IL4

A

Th2 T cells

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11
Q

Target: IL12

A

NK cells, T cells

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12
Q

Function: IFNα/IFNβ

A
  • Antiviral immunity
  • Increase class I MHC expression
  • Activate NK cells
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12
Q

Source: IL13

A

Th2 T cells

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13
Q

Function: IL4

A

Isotype switching in B cells to IgE

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15
Q

Function: IL2

A

Mitogen for activated (mature) naiive T cells

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16
Q

Source: IL12

A

Dendritic cells, macrophage

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17
Q

Function: IL5

A

Isotype switching in B cells to IgE

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18
Q

Function: IFNγ

A
  • Activate macrophage
  • Isotype switching in B cells to IgG
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19
Q

Source: IL8 & other chemokines

A

Macrophages, dendritic cells, endothelia, T cells

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20
Q

Source: IL10

A

Macrophages, dendritic cells, Th2 cells

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21
Q

Source: IL2

A

Activated T cells

22
Q

Function: IL7

A

Mitogen for developing immature lymphocytes

22
Q

Target: GM-CSF

A

Immature myeloid cells

23
Q

Function: G-CSF

A
  • Mitogen for myeloid progenitor cells
  • Immune suppression
24
Q

Target: IL13

25
Q

Function: IL15

A
  • Mitogen for NK cells
  • IFNγ production
25
Q

Source: IL17

A

Th17 T cells

25
Q

Target: IL6

A

liver, B cells

26
Q

Target: TGFβ

A

T cells, B cells

28
Q

Source: IL6

A

Macrophages, endothelial cells, T cells

29
Q

Source: GM-CSF

A

Macrophages, T cells

30
Q

Target: IL10

A

macrophages, dendritic cells, T cells

32
Q

Function: IL10

A
  • Inhibit IL12 production
  • Reduce MHC class II and costimulatory molecule expression
33
Q

Source: TGFβ

A

epithelia, NK cells, Tregs, fibroblasts, endothelia, others

34
Q

Target: IL1

A

enodthelia, hypothalamus, liver

35
Q

Source: IL1

A

Macrophages, endothelial cells

36
Q

Target: IL23

37
Q

Target: IL15

39
Q

Function: IL1

A
  • Activation (inflammation)
  • Fever
  • Acute phase protein synthesis
40
Q

Function: IL23

A

Promote Th17 differentiation

42
Q

Function: IL12

A
  • Increase IFNγ secretion
  • Increase cytotoxic activity
  • Th1 differentiation
42
Q

Target: IL2

A

Autocrine activated T cells

44
Q

Source: IL7

A

bone marrow, stromal cells

45
Q

Function: TNF

A
  • Activation (inflammation)
  • Activation/oxidative burst
  • Fever, acute phase protein synthesis, cachexia
46
Q

Target: IL17

A

PMNs, epithelia

48
Q

Source: IL5

A

Th2 T cells

49
Q

Source: IL18

A

macrophages

50
Q

Source: IFNα

A

Dendritic cells

51
Q

Target: IL8 & other chemokines

A

leukocytes

53
Q

Function: IL13

A

Isotype switching in B cells to IgE

54
Q

Source: IFNβ

A

Fibroblasts

55
Q

Source: IL23

A

Dendritic cells, macrophage

56
Q

Function: TGFβ

A
  • Suppress Th1 and Th2 development
  • Promote Th17 differentiation
  • Increase B cell IgA isotype switching
58
Q

Target: IL7

A

Immature T and B lymphocytes

59
Q

Target: TNF

A

endothelia, epithelia, neutrophils, hypothalamus, liver, muscle

60
Q

Target: G-CSF

A

Immature myeloid cells

61
Q

Target: IFNα

62
Q

Function: GM-CSF

A
  • Mitogen for myeloid progenitor cells
  • Immune suppression

Immunology (9 decks)

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