Cytokine Review Table Flashcards
1
Q
Function: IL17
A
- Activate / Mitogen for PMNs
- Increase antimicrobial peptides
2
Q
Function: IL8 & other chemokines
A
- PMN chemotaxis
- Leukocyte migration
- Dendritic cell lymph node migration
2
Q
Target: IFNβ
A
All cells
2
Q
Target: IL18
A
NK cells
3
Q
Target: IL4
A
B cells
4
Q
Source: G-CSF
A
macrophages, T cells
5
Q
Function: IL6
A
- Acute phase protein synthesis
- Proliferation of antibody producing B cells
5
Q
Target: IFNγ
A
macrophage, B cell
6
Q
Source: TNF
A
macrophage, T cells
7
Q
Target: IL5
A
B cell
8
Q
Source: IFNγ
A
Th1 T cells
9
Q
Source: IL15
A
macrophages
10
Q
Function: IL18
A
- Mitogen for NK cells
- IFNγ production
11
Q
Source: IL4
A
Th2 T cells
11
Q
Target: IL12
A
NK cells, T cells
12
Q
Function: IFNα/IFNβ
A
- Antiviral immunity
- Increase class I MHC expression
- Activate NK cells
12
Q
Source: IL13
A
Th2 T cells
13
Q
Function: IL4
A
Isotype switching in B cells to IgE
15
Q
Function: IL2
A
Mitogen for activated (mature) naiive T cells
16
Q
Source: IL12
A
Dendritic cells, macrophage
17
Q
Function: IL5
A
Isotype switching in B cells to IgE
18
Q
Function: IFNγ
A
- Activate macrophage
- Isotype switching in B cells to IgG
19
Q
Source: IL8 & other chemokines
A
Macrophages, dendritic cells, endothelia, T cells
20
Q
Source: IL10
A
Macrophages, dendritic cells, Th2 cells
21
Source: IL2
Activated T cells
22
Function: IL7
Mitogen for developing immature lymphocytes
22
Target: GM-CSF
Immature myeloid cells
23
Function: G-CSF
* Mitogen for myeloid progenitor cells
* Immune suppression
24
Target: IL13
B cell
25
Function: IL15
* Mitogen for NK cells
* IFNγ production
25
Source: IL17
Th17 T cells
25
Target: IL6
liver, B cells
26
Target: TGFβ
T cells, B cells
28
Source: IL6
Macrophages, endothelial cells, T cells
29
Source: GM-CSF
Macrophages, T cells
30
Target: IL10
macrophages, dendritic cells, T cells
32
Function: IL10
* Inhibit IL12 production
* Reduce MHC class II and costimulatory molecule expression
33
Source: TGFβ
epithelia, NK cells, Tregs, fibroblasts, endothelia, others
34
Target: IL1
enodthelia, hypothalamus, liver
35
Source: IL1
Macrophages, endothelial cells
36
Target: IL23
T cells
37
Target: IL15
NK cells
39
Function: IL1
* Activation (inflammation)
* Fever
* Acute phase protein synthesis
40
Function: IL23
Promote Th17 differentiation
42
Function: IL12
* Increase IFNγ secretion
* Increase cytotoxic activity
* Th1 differentiation
42
Target: IL2
Autocrine activated T cells
44
Source: IL7
bone marrow, stromal cells
45
Function: TNF
* Activation (inflammation)
* Activation/oxidative burst
* Fever, acute phase protein synthesis, cachexia
46
Target: IL17
PMNs, epithelia
48
Source: IL5
Th2 T cells
49
Source: IL18
macrophages
50
Source: IFNα
Dendritic cells
51
Target: IL8 & other chemokines
leukocytes
53
Function: IL13
Isotype switching in B cells to IgE
54
Source: IFNβ
Fibroblasts
55
Source: IL23
Dendritic cells, macrophage
56
Function: TGFβ
* Suppress Th1 and Th2 development
* Promote Th17 differentiation
* Increase B cell IgA isotype switching
58
Target: IL7
Immature T and B lymphocytes
59
Target: TNF
endothelia, epithelia, neutrophils, hypothalamus, liver, muscle
60
Target: G-CSF
Immature myeloid cells
61
Target: IFNα
All cells
62
Function: GM-CSF
* Mitogen for myeloid progenitor cells
* Immune suppression
