Cytokine Function and Site Flashcards
IL-1 (Principle Cell Source and Functions)
Principle Cell Source: Macrophages, monocytes, endothelial cells, neutrophils
Functions: Fever, Pro-inflammatory
IL-2
Principle Cell Source: CD4 and CD8 T cells
Functions: Activate and proliferate T cells/NK
IL-4
Principle Cell Source: CD4 (Th2) T cells, mast cells
Functions: B cell to IgE, differentiation of Th2, M2 macrophage differentiation
IL-5
Principle Cell Source: CD4 T cells and mast cells
Functions: Activation of eosinophils
IL-6
Principle Cell Source: Mø, endothelial cells, T cells, B cells,
Functions: Acute phase proteins, Th17 differentiation, pro-inflammatory, Activate B cells
IL-8
Principle Cell Source: Macrophages, mast cells
Functions: Chemotactic factor recruits and activates neutrophils
IL-10
Principle Cell Source: Macrophages, B cell, Tcell
Functions: Anti-inflammatory, self-tolerance
IL-12 (IL-18)
Principle Cell Source: Macrophages, DCs
Functions: Th1 differentiation, induce T/NK to produce IFN-G
IL-13
Principle Cell Source: Th2 cells
Functions: M2 macrophage activation
IL-15
Principle Cell Source: Macrophages, epithelial cells
Functions: Proliferation of NK and T cells
IL-17
Principle Cell Source: Th17 cells
Functions: Neutrophilic inflammation
IL-7
Principle Cell Source: ?
Functions: prolif/differentiation of lymphocytes in primary lymphoid tissue
TNF-A
Principle Cell Source: macrophages, monocytes, T/NK cells, Neutrophils
Functions: integrin/Eselectin activation, Shock, Cachexia, Major pro-inflammatory
TGF-B
Principle Cell Source: Macrophages (M2), T regulatory cells
Functions: Wound healing, tissue repaid, inhibition of T cell activation, Th17 differentiation, IgA switching (BAFF,APRIL), ANTIINFLAMMATORY
IFN-Gamma
Principle Cell Source: NK cells, Th1 cells, CTLs
Functions: activate macrophages (m1), IgG isotype switching
