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RANZCP exam preparation > Cytochrome p450 > Flashcards

Cytochrome p450 Flashcards

1
Q

CYP1A2: Substrates

A

CYP1A2 Substrates

Alosetron (Lotronex)
Caffeine
Clozapine (Clozaril)
Flutamide (Eulexin)
Frovatriptan (Frova)
Melatonin
Mexiletine (Mexitil)
Mirtazapine (Remeron)
Olanzapine (Zyprexa)
Ramelteon (Rozerem)
Rasagiline (Azilect)
Ropinirole (Requip)
Tacrine (Cognex)
Theophylline
Tizanidine (Zanaflex)
Triamterene (Dyrenium)
Zolmitriptan (Zomig)
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2
Q

CYP1A2 inhibitor

A

CYP1A2 Inhibitors

Artemisinin
Atazanavir (Reyataz)
Cimetidine (Tagamet)
Ciprofloxacin (Cipro)
Enoxacin
Ethinyl Estradiol
Fluvoxamine
Mexiletine
Tacrine (Cognex)
Thiabendazole
Zileuton (Zyflo)

Herbal teas
Cumin
Tumeric

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3
Q

CYP1A2 inducers

A 
Tobacco
Brocolli, brussel sprouts, chargrilled meat, cauliflower
Insulin
Modafanil
Omeprazole
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4
Q

CYP2C19 substrates, inhibitors, inducers

A 
S:
TCA
SSRIs
Antiepileptics
Diazepam
Gliclazide
PPI
Inh:
Moclobemide
Fluvoxamine
Topiramate
Valproate (weak)
Carbamazepine (weak)

Ind:
Carbamazepine
Norethistone
Prednisone

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5
Q

CYP2C29 substrates, inhibitors, inducers

A 
S:
NSAIDS
Phenytoin
Sulfonylureas
Amitryptilline
Fluoxetine

Inh:

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RANZCP exam preparation (14 decks)

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