Cytochrome p450 Flashcards
What is the acronym for drugs that are metabolised by cytochrome p450?
5COW P(2)A(2)T(2)S PTSDD
What are the anti convulsant drugs that are metabolised by cytochrome p450?
Carbamazepine and phenytoin
What anticoagulant drug is metabolised by p450?
Warfarin
What contraceptive drug is metabolised by p450?
oral contraceptive
What immunosuppression drugs are metabolised by p450?
Ciclosporin
Tacrolimus
What is the acronym for drugs that induce p450?
CRAP GPS
What is the anti convulsant drugs that induce p450?
Carbamazepine and phenytoin
What antiviral drug is metabolised by p450?
Protease inhibitor
What antibiotic induce p450?
Rifmapicin
What is the action of alcohol on p450?
Chronic alcohol induces p450
Acute bing alcohol inhibits p450
What flowering part induces p450?
St jon Wart
What antihypertensive medication is metabolised and inhibitor of p450?
Diltiazem (calcium channel blocker)
What pain medication is metabolised by p450?
Painkiller/paracetamol
What abx is metabolised by p450?
Metronidazole
What is the acronym for inhibitors of p450?
SICK FACES. COM GROUP
What anticonvulsant inhibit p450?
Sodium valproate
What cholesterol controlling is metabolised by p450?
Statin
What non drug substances induce p450?
Put in your mouth= Charcoal meat and cigarettes
What respiratory drug is metabolised by p450?
Theophylline
What are the antibiotics that are inhibit of p450?
Ciprofloxacin Sulphonamides Chloramphenicol Isoniazid Metronidazole Erythromycin
What anti depressants are metabolised by p450?
Citalopram= SSRI
TCA
What alzheimer drug is metabolised by p450?
Acetylcholine inhibitor = donepezil
What type of steroids is metabolised by p450?
Corticosteroids
Give example of a drug given for alcohol withdrawal that is metabolised by p450?
Diazepam (BZDP)
What diabetic drug induces p450?
Sulphonylureas
What anti fungal drug induces p450?
Griseolfine
What drugs that regulate stomach acid production is metabolised by p450?
PPI
What drugs that regulate stomach acid production inhibits p450?
Cimetidine = H2 antagonist Omeprazole= PPI
What antifungals inhibits p450?
Ketoconazole
Fluconazole
Juice of what fruit inhibits p450?
Grape fruit juice
What anticoagulant drug is activated by p450?
Clopidogrel
What potassium channel blocker drug is metabolised by p450 and inhibits p450?
Amiodarone
What vitamins are metabolised by p450?
Vitamin D/ca
What thyroid drug is inhibitory of p450?
Thyroxine
What rate rhythm drug is metabolised by p450?
digoxin
What old school epileptic drug is inducer of p450?
Phenobarbitone
