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year 3 OSCE > Cytochrome p450 > Flashcards

Cytochrome p450 Flashcards

1
Q

What is the acronym for drugs that are metabolised by cytochrome p450?

A

5COW P(2)A(2)T(2)S PTSDD

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2
Q

What are the anti convulsant drugs that are metabolised by cytochrome p450?

A

Carbamazepine and phenytoin

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3
Q

What anticoagulant drug is metabolised by p450?

A

Warfarin

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4
Q

What contraceptive drug is metabolised by p450?

A

oral contraceptive

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5
Q

What immunosuppression drugs are metabolised by p450?

A

Ciclosporin

Tacrolimus

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6
Q

What is the acronym for drugs that induce p450?

A

CRAP GPS

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7
Q

What is the anti convulsant drugs that induce p450?

A

Carbamazepine and phenytoin

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8
Q

What antiviral drug is metabolised by p450?

A

Protease inhibitor

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9
Q

What antibiotic induce p450?

A

Rifmapicin

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10
Q

What is the action of alcohol on p450?

A

Chronic alcohol induces p450

Acute bing alcohol inhibits p450

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11
Q

What flowering part induces p450?

A

St jon Wart

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12
Q

What antihypertensive medication is metabolised and inhibitor of p450?

A

Diltiazem (calcium channel blocker)

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13
Q

What pain medication is metabolised by p450?

A

Painkiller/paracetamol

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14
Q

What abx is metabolised by p450?

A

Metronidazole

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15
Q

What is the acronym for inhibitors of p450?

A

SICK FACES. COM GROUP

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16
Q

What anticonvulsant inhibit p450?

A

Sodium valproate

17
Q

What cholesterol controlling is metabolised by p450?

A

Statin

18
Q

What non drug substances induce p450?

A

Put in your mouth= Charcoal meat and cigarettes

19
Q

What respiratory drug is metabolised by p450?

A

Theophylline

20
Q

What are the antibiotics that are inhibit of p450?

A 
Ciprofloxacin 
Sulphonamides
Chloramphenicol
Isoniazid
Metronidazole 
Erythromycin
21
Q

What anti depressants are metabolised by p450?

A

Citalopram= SSRI

TCA

22
Q

What alzheimer drug is metabolised by p450?

A

Acetylcholine inhibitor = donepezil

23
Q

What type of steroids is metabolised by p450?

A

Corticosteroids

24
Q

Give example of a drug given for alcohol withdrawal that is metabolised by p450?

A

Diazepam (BZDP)

25
Q

What diabetic drug induces p450?

A

Sulphonylureas

26
Q

What anti fungal drug induces p450?

A

Griseolfine

27
Q

What drugs that regulate stomach acid production is metabolised by p450?

A

PPI

28
Q

What drugs that regulate stomach acid production inhibits p450?

A 
Cimetidine = H2 antagonist
Omeprazole= PPI
29
Q

What antifungals inhibits p450?

A

Ketoconazole

Fluconazole

30
Q

Juice of what fruit inhibits p450?

A

Grape fruit juice

31
Q

What anticoagulant drug is activated by p450?

A

Clopidogrel

32
Q

What potassium channel blocker drug is metabolised by p450 and inhibits p450?

A

Amiodarone

33
Q

What vitamins are metabolised by p450?

A

Vitamin D/ca

34
Q

What thyroid drug is inhibitory of p450?

A

Thyroxine

35
Q

What rate rhythm drug is metabolised by p450?

A

digoxin

36
Q

What old school epileptic drug is inducer of p450?

A

Phenobarbitone

year 3 OSCE (14 decks)

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