Cysts and Odontogenic Tumors 2 Flashcards
• Posterior jaws of teenagers, young adults
• Aggressive growth with 30% recurrence
• A unilocular or multilocular radiolucency; imitates other
lucencies
OKC
Where are OKCs mostly found in mouth? What age?
• Posterior jaws of teenagers, young adults
- Primordial cysts 50%
- Lateral periodontal 25%
- Dentigerous 10%
- Globulomaxillary 10%
OKC
Compact epithelium, no rete ridges, 8 to 10 cell layers thick
• Corrugated surface parakeratin
• Prominent, palisaded, hyperchromatic basal layer
OKC
- Aggressive behavior
- Recurrence - 30%
- Nevoid Basal Cell Carcinoma Syndrome
OKC
• Syndrome-associated OKC –multiple OKCs common in the
_______
nevoid basal cell carcinoma syndrome
• Autosomal dominant - highly penetrant and variably
expressive
• Mutation in PTCH (PATCHED) tumor supressor gene at
9q22.3
nevoid basal cell carcinoma syndrome
- Skeletal anomalies
- Bifid ribs
- Jaw cysts
- Multiple OKCs
- Skin tumors
- Multiple, early onset basal cell carcinomas
- Neoplasms
- CNS –Medulloblastoma
nevoid basal cell carcinoma syndrome
Daughter cysts are seen in what disease process?
OKC
Ghost cells are seen in what disease process?
Calcifying Odontogenic cyst
• A developmental odontogenic cyst with an orthokeratin
lining, NOT parakeratin
• Originally described as the “orthokeratinized variant of the
odontogenic keratocyst”
• Does not behave as an odontogenic keratocyst
- no recurrence
Orthokeratinizing
Odontogenic Cyst
- Gorlin cyst, calcifying and keratinizing odontogenic cyst
- Anterior jaws of adults
- Radiolucent to mixed
- Ghost cells
- Sometimes associated with
Calcifying Odontogenic Cyst
(Gorlin Cyst)
• WHO: Calcifying Cystic Odontogenic Tumor
Where in the mouth and what age are Calcifying Odontogenic Cyst
(Gorlin Cyst) seen?
Anterior maxilla of adults
• Sialodontogenic cyst –an odontogenic cyst with glandular
(salivary) features
• Anterior jaws of middle-aged adults, mandible > maxilla
• Commonly multilocular, crosses midline
• Aggressive behavior - 30% recurrence
Glandular Odontogenic Cyst
Can a lesion be an OKC with a mixed RO/ Radio lucent appearance?
No must be fully RL
• Soft tissue cyst of upper lip lateral to midline
• Developmental cyst, remnants of nasolacrimal duct
• Adult females (3:1)
-Moves the ala of nose
Nasolabial Cyst
• Nasoalveolar cyst, Klestadt cyst
- Cystic change of crypt epithelium of lymphoid aggregate
- Young adults
- Waldeyer’sring
- Tonsillar pillar
- Floor of mouth
- Ventral tongue
Oral Lymphoepithelial Cyst
• Cystic change of branchial epithelium
• Upper lateral neck anterior to border of sternocleidomastoid
muscle in young adults
Cervical Lymphoepithelial Cyst
• Branchial Cleft Cyst
- Cystic change of thyroglossal tract epithelium
* Midline of neck in young people
Thyroglossal Duct Cyst
Histo of _______:
• Stratified squamous epithelial lining exhibiting lymphoid
tissue with or without germinal centers in wall
Cervical Lymphoepithelial Cyst
- Empty cavity - not a true cyst
- Trauma-hemorrhage theory of origin
- Male (2:1)
- Teenagers –young adults
- Mandible
- Lucency
- Scalloped border frequent
- Asymptomatic
- Expansion rare (20%)
- Vital teeth
- Biopsy initiates healing
Traumatic bone cyst
Is root resorption ever seen in a traumatic bone cyst?
Never
- Young individuals < 20 years
- Rapidly growing, may blow out the cortex, painful
- Mandible most commonly
- Lucency, frequently multilocular
Aneurysmal Bone Cyst
Surgical Findings of ________:
• Ballooning dilation of bone
• Blood welling up from within the cavity, like a blood-soaked
sponge
• Fleshy aggregates of tumor surrounding cystic spaces filled
with blood
• Hemosiderin pigmentation
Aneurysmal Bone Cyst
Histo of ______:
• Not a true cyst
• Cyst-like cavities, filled with blood
• Multinucleated giant cells
Aneurysmal Bone Cyst
- Asymptomatic
- Radiolucency below inferior alveolar nerve canal
- Submandibular gland
Stafne cyst
