Bone Diseases 5

Question 1

Altered condition of bone 
Normal bone replaced
Proliferation of fibrous 
connective tissue
New mineralized component

Answer 1

BENIGN FIBRO-OSSEOUS LESION

Question 2

 Monostotic: Common
 Craniofacial
 Polyostotic: Rare
 McCune-Albright Syndrome: Severe - Cafe Au Lait Macules
 Bone, skin and endocrine lesions
 Jaffe-Lichtenstein Syndrome: Mild
 Bone and skin lesions only

Answer 2

Fibrous dysplasia

Question 3

What 2 syndromes are associated with fibrous dysplasia?

Answer 3

McCune Albright

Jaffe Lichtenstein

Question 4

Diffuse homogenous RO
Ground glass appearance
Orange peel appearance
Chinese characters

Answer 4

Fibrous dysplasia

Question 5

 Postzygotic GNAS 1 gene mutation – codes for a G-protein and results in hyperfunction of cells in the involved
tissues
 Clinical severity: depends on the point in time the mutation occurs.
 Early embryonic life in undifferentiated stem cell
 Osteoblasts - Multiple bone lesions
 Melanocytes - Cutaneous pigmentation
 Endocrine cells - Endocrine disturbances
 Later embryonic life in skeletal progenitor cell
 Osteoblasts - Multiple bone lesions, cutaneous pigmentation
 Postnatal life
 Osteoblasts - Single bone lesion

Answer 5

Fibrous dysplasia

Question 6

Benign fibro-osseous process
Abnormal reaction of bone
The most common benign fibro-osseous lesion of the jaws
Probably arises from elements of the periodontal ligament

Answer 6

CEMENTO-OSSEOUS DYSPLASIA

Question 7

 A benign fibro-osseous lesion 
located in the periapical region of 
anterior mandible
 Females (10:1)
 Blacks 70%
 Ages 30 to 50 years
 Asymptomatic, associated with vital 
teeth
 Solitary or multiple
 Early lesions lucent

Answer 7

PERIAPIACAL CEMENTO-OSSEOUS

DYSPLASIA

Question 8

 Middle-aged adults, strong racial predominance for
African-Americans, strong female gender predominance
 Multifocal involvement, often bilateral and symmetric, four
quadrant involvement not unusual
 Lucent – mixed – opaque, with thin peripheral radiolucent
rim
 Usually asymptomatic, possibly dull pain, expansion rare
 Associated with simple bone cysts

Answer 8

FLORID CEMENTO-OSSEOUS

DYSPLASIA

Question 9

 Middle-aged adults (Mean = 38 y)
 Strong female gender 
predominance
 Possible racial predominance
 Posterior mandible 
commonly
 Frequently in extraction site
 Thin peripheral radiolucent 
rim

Answer 9

FOCAL CEMENTO-OSSEOUS

DYSPLASIA

Question 10

 Benign neoplasm
 Age 20 to 40 years
 Female predilection
 Molar and pre-molar region of mandible, most frequently
 Radiolucent to mixed
 Expansion, may displace teeth
 May arise from elements of the periodontal ligament

Answer 10

Cemento-ossifying fibroma

Question 11

How will the cemento-osseous dysplasia lesion come out in a biopsy? one piece or many pieces

Answer 11

Many pieces

Question 12

How will the cemento-ossifying fibroma lesion come out in a biopsy? one piece or many pieces

Answer 12

Comes out in 1 piece

Question 13

Does ossifying fibroma or fibrous dysplasia have expansion?

Answer 13

Ossifying fibroma