CVD Flashcards
How many years does QRISK 2 and 3 predict
10 years
What years does JBS3 calculator predict
Lifetime
How many years does Assign predict
10 years
Overview of CVD
When are these calculators not appropriate
Diabetes type 1
Established CVD
CKD
Family hypercholesterolemia
Risk increases with age
Primary and secondary prevention
Why is it important to correct hypothyroidism first before correcting cholesterol
When thyroid is low, LDL cholesterol builds in the body
What tests are done before statins are initiated
Full lipid profile, liver function (3 +12 months), renal function, HBA1c before and during, thyroid
What are some SE of statins
Myopathy and rhabdomyolysis (test creatinine kinase)
Liver impairment
Liver impairment
When should simvastatin be given
Night
When can atorvastatin and rosuvastatin be given?
Anytime (longer half life)
What statin is given for primary prevention
Atorvastatin 20mg
What statin is given for secondary prevention
Atorvastatin 80mg
Should rostuvastatin be given to Asian patients
No
When does it not matter about serum cholesterol levels
Type 1 diabetes - all patients
Chronic kidney disease
Family history
Lipid ranges
Statin treatment overview
What can happen when you give statin and fibrates especially like gemifabrozil
SE like rhabdomyolysis - monitor liver and creatinine kinase
How many months should statins be discontinued before pregnancy
3 months
How long should contraception be used for
During treatment and one month after
What should you report
Muscle pain
What can simvastatin 80mg cause
Rhabdomyolysis
What is the max dose of simvastatin when given with amlodipine?
20mg - any more then risk of rhabdomyolysis
Interactions of statins with amiodarone, colcicine, nicotinic acid
increase risk of rhabdomyolysis
