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Cardiovascular > CVD > Flashcards

CVD Flashcards

1
Q

How many years does QRISK 2 and 3 predict

A

10 years

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2
Q

What years does JBS3 calculator predict

A

Lifetime

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3
Q

How many years does Assign predict

A

10 years

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4
Q

Overview of CVD

A
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5
Q

When are these calculators not appropriate

A

Diabetes type 1

Established CVD

CKD

Family hypercholesterolemia

Risk increases with age

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6
Q

Primary and secondary prevention

A
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7
Q

Why is it important to correct hypothyroidism first before correcting cholesterol

A

When thyroid is low, LDL cholesterol builds in the body

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8
Q

What tests are done before statins are initiated

A

Full lipid profile, liver function (3 +12 months), renal function, HBA1c before and during, thyroid

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9
Q

What are some SE of statins

A

Myopathy and rhabdomyolysis (test creatinine kinase)

Liver impairment

Liver impairment

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10
Q

When should simvastatin be given

A

Night

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11
Q

When can atorvastatin and rosuvastatin be given?

A

Anytime (longer half life)

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12
Q

What statin is given for primary prevention

A

Atorvastatin 20mg

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13
Q

What statin is given for secondary prevention

A

Atorvastatin 80mg

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14
Q

Should rostuvastatin be given to Asian patients

A

No

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15
Q

When does it not matter about serum cholesterol levels

A

Type 1 diabetes - all patients

Chronic kidney disease

Family history

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16
Q

Lipid ranges

A
17
Q

Statin treatment overview

A
18
Q

What can happen when you give statin and fibrates especially like gemifabrozil

A

SE like rhabdomyolysis - monitor liver and creatinine kinase

19
Q

How many months should statins be discontinued before pregnancy

A

3 months

20
Q

How long should contraception be used for

A

During treatment and one month after

21
Q

What should you report

A

Muscle pain

22
Q

What can simvastatin 80mg cause

A

Rhabdomyolysis

23
Q

What is the max dose of simvastatin when given with amlodipine?

A

20mg - any more then risk of rhabdomyolysis

24
Q

Interactions of statins with amiodarone, colcicine, nicotinic acid

A

increase risk of rhabdomyolysis

25
Q

Interactions of statins and carbamazepine

A

increase risk of hepatotoxicity

26
Q

Interactions of statins with clarithromycin/erythromycin

A

increased exposure to simvastatin

27
Q

Interactions of statins and grapefruit juice

A

Increases exposure

28
Q

Interactions of statins with ketonazole/miconazole

A

Increase exposure

29
Q

Interactions of statins and amlodipine

A

Risk of rhabdomyolysis

30
Q

Important dose adjustments

A
31
Q

Inducers and inhibitors

A

Cardiovascular (8 decks)

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