CV Exam (review, shuffled) Flashcards

1
Q

Optimal HDL level in men? Women?

A

Men: >40
Women: >50

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2
Q

Read everything important about IgA Vasculitis.

A
  • Formerly Henoch-Schonlein Purpura
  • IgA complex deposition –> complement activation
  • *Mostly affects children
  • *Recent antecedent infection common (usually upper respiratory tract- IgA protects mucosal sites)
  • P/w palpable purpura in buttocks/legs, GI pain/bleeding, hematuria (IgA nephropathy)
  • Self-limited, may recur. Steroids for severe tx.
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3
Q

What enzyme is upregulated with use of bile acid-binding resins?

A

Cholesterol 7alpha-hydroxylase

rate-limiting step of bile acid synthesis

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4
Q

Name another vasodilator we need to know besides nitropresside and hydralazine.

A

Minoxidil (if other drugs are resistant)

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5
Q

Pts w/what dz’s should not take mannitol?

A
  • CHF
  • Renal failure (chronic)
  • Pulmonary edema (extracts water from cells)
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6
Q

Name the drug classes that can be used in the treatment of CHRONIC CHF.

A
  1. Diuretics (except CA-inhibitors/mannitol)
  2. ACEIs/ARBs
  3. BBs
  4. Digoxin
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7
Q

What types of angina are Nitrates used in? CCBs?

BBs?

A

All 3
All 3
Stable and unstable (not variant)

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8
Q

What is SREBP?

A

TS factor activated by statin’s action, which increases LDL-receptor expression (binds B100)

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9
Q

What is PPAR-alpha? (give detail)

A

Fibrates are ligands for the PPAR-alpha receptor. Leads to:
A. Decreased ApoC3/increased LPL expression –> increased FA oxidation –> decreased VLDL synthesis –> increased VLDL clearance.
B. Increased apoA1 expression –> increased HDL production.

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10
Q

Which statins are affected by CYP3A4 inducers/inhibitors?

A

LSA:

Lovastatin, sivastatin, atorvastatin

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11
Q

PCSK9 inhibitors’ effects on % reductions/increases of serum lipids:

A

v LDL (> 50%)

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12
Q

Causes of dilated cardiomyopathy?

A
ABCCCD
Alcohol abuse
Beriberi (wet)
Coxsackie B viral myocarditis
Cocaine abuse (chronic)
Chagas disease
Doxorubicin

(+hemochromatosis, sarcoidosis, peripartum)

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13
Q
  1. Which loop diuretic is 40x more potent than furosemide, but has a shorter T1/2?
  2. Which has a longer T1/2?
A
  1. Bumetanide

2. Torsemide

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14
Q

Name 3 drugs safe to use during pregnancy to treat HTN.

A

Alpha-methyl DOPA
Beta-blockers
Hydralazine

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15
Q
Ivabradine: 
MoA?
Indications?
Toxicity?
Contraindications?
A
  • Blocks If current in SA nodal fibers. (starts w/letter “I”) Prevents exercise-induced myocardial ischemia.
  • Chronic stable angina
  • Bradycardia; heart block; luminous phenomenon
  • Sick Sinus Syndrome; use with non-dihydropyridine CCBs
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16
Q
  1. Which CA inhibitor is ~ 30x more potent than acetazolamide?
  2. About 5x more potent than acetazolamide?
  3. Topical preparation for ocular use–avoids systemic effects?
A
  1. Dichlorphenamide
  2. Methazolamide
  3. Dorzolamide
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17
Q

What drug class is DOC for uncomplicated (mild-mod) HTN?

A

Diuretics (along w/lifestyle mods)

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18
Q

Which statin is unaffected by CYP450 metabolism?

A

Pravastatin

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19
Q

When are 2 combined HTN drugs recommended, numerically?

A

When BP >20/10 over

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20
Q

What are the killer chest pains?

A
  • ACS
  • Tension PTX
  • PE
  • Dissecting aneurysm
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21
Q

What is ANCA?

Explain the 2 types

A

Anti-neutrophil cytoplasmic antibody
- ABs directed against neutrophilic granules (mostly against enzymes)
pANCA: anti-myeloperoxidase
cANCA: anti-proteinase 3
- ANCA formation induced by drugs or cross-reactive microbial antigen (autoimmune, infections, malignancies).
ANCA binds these cells, further activating. ANCA activated neutrophils –> release lytic granules and ROS–> vascular dmg.

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22
Q

What drug class might you combine with a vaso- and arterio-dilators to reduce the reflex tachycardia?

A

Beta-blockers

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23
Q

ranges for desirable, borderline, and high cholesterol?

A
  • Desirable: < 200
  • Borderline: 200-240
  • High: > 240
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24
Q

Read everything important about Granulomatosis w/Polyangiitis.

A
  • Formerly Wegener’s Granulomatosis (“c”)
  • Nectrotizing, granulomatous
  • Commonly involves *nasopharynx, lungs, kidneys (“C”)
  • Classic: middle-aged male w/sinusitis/nasopharyngeal ulcer, hemoptysis, bil. nodular lung infiltrates, and hematuria due to rapid progressing glomerulonephritis (can become crescentic- obliterates glumerulus)
  • *c-ANCA (correlates w/dz activity)
  • Also a/w saddle-nose deformity, mononeuritis multiplex, necrotizing scleritis, palpable purpura, orbital pseudotumor, etc., arthritis
  • Tx: corticosteroids w/cyclophosphamide, relapses common (“c”)
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25
Q

List the non-pharmacological therapies for CHRONIC CHF.

A
  • Surgical therapy–revascularization for ischemic heart dz–valve repair/replacement for valvular heart dz–aneurysmectomy
  • LVADs (bridge to transplant or destination therapy)
  • Biventricular pacing: cardiac resynchronization therapy (CRT) +/- implantable cardiac defibrillators (ICDs)
  • Cardiac transplantation
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26
Q

Stress tests are ___% sensitive, maybe ___% specific

A

60

80

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27
Q

Patients taking short-acting nifedipine, diltiazem or verapamil were 1.6 times more
likely to have __________. (dz)

A

MI

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28
Q

Which ACEI allows for once daily dosing?
Which has a shorter T1/2?
Which has a longer T1/2?

A

Lisinopril
Captopril
Enalapril

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29
Q

What is the pathology of MVP?

A

Unknown

- Usually asymptomatic

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30
Q

Explain furosemide pharmacokinetics.

A

Half-life is short (1-1.5 hrs) so duration is only 2-3 hrs. Renal secretion mechanism; organic acid transporter.

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31
Q

In hypertensive emergency, you only wan to lower BP 25-30% in the first 24 hrs. What 2 dz’s are exceptions?

A
  • Dissecting Aneurysm: rapidly (20mins) lowered to 100-120 mmHg
  • Acute phase of ischemic stroke: reperfusion candidates
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32
Q

Is a non-dihydropyradine w/a beta-blocker a good or bad combo?

A

Bad (conduction disturbances)

- “Use w/caution”

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33
Q

Which statins are affected by CYP2C9 inducers/inhibitors?

A

FR

Fluvastatin, rosuvastatin

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34
Q

What is NCPL1?

A

Membrane protein that mediates intestinal cholesterol absorption, inhibited by ezetimibe.

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35
Q

What is the major side effect of lomitapide and mipomerson?

A

Hepatotoxicity.

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36
Q

NCEP ATP III ranges for optimal/desirable, near/above optimal, borderline high, high, and very high levels of LDL?

A
  • Optimal/desirable: < 100
  • Near/above optimal: 100-129
  • Borderline high: 130-159
  • High: 160-189
  • Very high: 190+
37
Q

3 drugs that prevent ventricular remodeling:

A
  • ACE Inhibitors/ARBs/LCZ696
  • Beta Blockers
  • Aldosterone Antagonists

(same + hydralazine w/nitrates)

  • ACE Inhibitors/ARBs/LCZ696
  • Hydralazine + Nitrates
  • Beta Blockers (carvedilol, metoprolol, bucindolol)
  • Aldosterone antagonists (spironolactone, eplerenone)
38
Q

Fibrates effects on % reductions/increases of serum lipids:

A

v TG (40-60%), v LDL (10-20%), ^ HDL (10-20%)

39
Q

Give the 3 examples of noninfected vegetations?

A
Acute Rheumatic Fever
Endocarditis of System Lupus Erythematosus
    (Liebman-Sacks Endocarditis)
Nonbacterial Thrombotic Endocarditis
		(Marantic Endocarditis)
40
Q

Bad Combo’s for treating HTN:

  • K+ sparing diuretics with _________________.
  • Combo of ACE-inhibitors and _________________ has no advantage in diabetics
A
  • ACE-inhibitors (exacerbate hyperkalemia)

- ARBs (risks of hyperkalemia are increased)

41
Q

List 5 predictive factors used to assess 10-year coronary heart disease risk based on the NCEP’s ATP III guidelines.

A
Age 
Diabetes 
Smoking 
Blood pressure categories 
NCEP total cholesterol categories 
LDL cholesterol categories
42
Q

Which statins does gemfibrozil affect, and how?

A

v OATP2/v Glucoronidation –> ^[all Statins]

43
Q

Read everything important about Giant Cell Arteritis.

A
  • Granulomatous (giant cells, epitheloid cells, exudate/necrosis) vasculitis, classically involves carotid a. (headaches), but also ophthalmic (visual disturbances, jaw claudication)
  • *>50 y/o, usually females
  • Polyarthralgia rheumatica (morning stiffness)
  • Elevated ESR, CRP
  • Mutation in HLA-DR4; T cell mediated (IL-6)
  • Bx reveals inflamed vessel w/giant cells, intimal fibrosis (destruction of IEL)
  • MR Angio useful when larger vessel
  • Tx: corticosteroids, high risk blindness w/o, anti-IL-6 AB
44
Q

Name the 4 consequences of cardiac remodeling, as occurs w/overproduction of renin.

A
  • Myocyte hypertrophy
  • Re-expression of fetal isoforms
  • Myocyte apoptosis
  • Changes in the interstitial matrix
45
Q
Ranolazine: 
MoA?
Indications?
Toxicity?
Contraindications?
A
  • Inhibits FA beta oxidation in cardiomyocyte mito. Prevents exercise-induced myocardial ischemia. (unknown mech)
  • Originally chronic stable angina unresponsive to other agents; now exercise-induced angina as well.
  • Prolonged QT
  • Long QT syndrome; contraindicated for use with other drugs that prolong QT interval.
46
Q

Name the 5 small vessel vasculides and their differentiating factors.

A

ANCA-ASSOCIATED
1. Granulomatosis w/ Polyangiitis: c-ANCA, nasopharynx
2. Eosinophilic Granulomatosis w/Polyangiitis: pANCA, asthma
3. Microscopic polyangiitis: pANCA
IMMUNE COMPLEX
1. IgA Vasculitis: antecedent infection, mostly kids
2. Cryoglobulinemic vasculitis: Hep. C

47
Q

What patients w/these 3 diseases would benefit from a beta-blocker to treat their HTN.

A

Diabetes, CHF, MI

48
Q

Read everything important about Cryoglobulinemic Vasculitis.

A
  • Three types of cryoglobulinemia
    Type I: Monoclonal Ig, immunoproliferative disorders
    Type II: Mixed (poly & monoclonal), chronic infection
    Type III: Mixed, autoimmune disorders
  • Typically type II or III
  • *Underlying hep. C common
  • Viral triggered, immune-complex mediated
  • Palpable purpura, weakness, Reynaud’s, multiplex mononeuritis
49
Q

Name the quantitative platelet disorders for your bleeding differential.

A
  1. ITP
  2. TTP-HUS
  3. Drug-induced
  4. Hypersplenism
  5. Neoplasm (invades marrow)
  6. Virus
  7. Autoimmune (eg Lupus)
  8. Gestational
  9. DIC
50
Q

What are the names of 2 drugs used to treat homozygous FH?

give MoA of each

A

Lomitapide: Inhibits MTP in both erythrocytes and liver –> decreased production of chylomicrons, VLDL, and LDL

Mipomerson: Antisense oligonucleotide specific for apoB48/100 –> decreased expression of apoB48/100 –> decreased VLDL & LDLs.

51
Q

Define: pulsus paradoxis, beck’s triad, and kussmaul sign.

What dz are they indicative of?

A
  • Pulsus paradoxis: Nlly BP decreases 10 mmHg w/inspiration (low T pressure allows for pulm veins to hold more blood), causing reflex tachy (blood overfills right side, pushing septum into left side). In cardiac tamponade, there’s nowhere for the blood to go because right ventricle is compressed, therefore LV can’t eject as much (?), so BP drops > 10mmHg. Heart sounds heard on chest, but no pulse on inspiration (pulse felt on expiration), and this is the paradox.
    Also seen in severe pulm dz
  • Beck’s triad: In cardiac tamponade: hypotension, quiet heart sounds (fluid covers it up), elevated JVP.
  • Kussmaul sign: Increased JVP w/inspiration
52
Q

Bile acid-binding resins (coles) effects on % reductions/increases of serum lipids:

A

v LDL (10-25%), small increase in TG

53
Q

Optimal triglyceride level?

Very high level?

A

< 150

> 500

54
Q

Ezetimibe’s effects on % reductions/increases of serum lipids:

A

v LDL (~18%)

55
Q

What drug is most effective at treating HTN in African Americans?
- Which would you avoid in this demo? (unless combined w/____)

A

CCBs (monotherapy) (hint- African Americans need something stronger)
- Beta blockers (+ diuretics)

56
Q

Read everything important about Takayasu Arteritis.

A
  • Granulomatous (monocytes, giant cells), vasculitis, often involves aortic arch at branch pts (*collaterals form, more common than in GCA)
  • Intimal hyperplasia, adventitial fibrosis
  • *Adults < 50 y/o (young azn females)
  • Visual sx, weak/absent pulse (“pulseless dz”), visual/neuro sx
  • HTN when renal a. involved
  • ESR elevated, but no specific marker
  • Tx: corticosteroids, anti-IL-6 AB
57
Q

Read everything important about Polyarteritis Nodosa.

A
  • Necrotizing vasculitis, multiple organs, *lungs are spared
  • Classically presents in young adults as HTN (renal a.), abd pain w/melena (*mesenteric a.), mononeuritis multiplex (sensory + motor; eg wrist drop), skin: livedo reticularis (rash)
  • Higher incidence in *hep. B pts
  • Early lesion: transmural inflammation w/fibrinoid necrosis, will heal w/fibrosis (nodosa)–string of pearls on x-ray.
  • Fatal if untreated
  • Tx: corticosteroids, cyclophosphamide, long term: methotrexate
58
Q

Name the drug classes that can be used in the treatment of ACUTE CHF.

A
  1. Furosemide
  2. Nitrates
  3. Niseritide (synthetic BNP)
  4. Beta-adrenergic agonists
  5. PDE-inhibitors (anamrinone, milrinone)
  6. Digoxin
59
Q

Read everything important about Eosinophilic Granulomatosis w/Polyangiitis.

A
  • Formerly Churg-Strauss Syndrome
  • Nectrotizing granulomatous inflammation w/eosinophils involving multiple organs, esp. lungs + heart
  • Similar to GPA, but no upper resp tract involvement (still affects triad)
  • *Asthma and peripheral eosinophilia present
  • *p-ANCA (correlates w/dz activity)
  • Phases
    1. Atopy, allergic rhinitis, asthma
    2. Eosinophilia
    3. Systemic vasculitis
  • Can also be a/w coronary arteritis (leading cause of death), cardiomyopathy, gastroenteritis
60
Q

Read everything important about Microscopic Polyangiitis.

A
  • Necrotizing vasculitis, multi-organ, esp. kidney, lung
  • Fibrinoid necrosis of media; leukocytoclastic
  • Similar presentation to GPA, but no nasopharyngeal involvement, no granulomas, and + *p-ANCA levels correlated w/dz activity.
  • Also similar to PAN, but smaller vessels
  • Tx: corticosteroids w/cyclophosphamide, relapses common. Use rituximab when severe.
61
Q

Etiologies of pericarditis?

A

Infections (Viruses, Bacteria, TB, Fungi, Parasites)
Immune-Mediated Reactions (Rheumatic fever, SLE, Post-cardiotomy, Post-MI, drug hypersensitivity)
Uremia
Neoplasia
Trauma
Radiation

62
Q

Causes of restrictive cardiomyopathy?

A
Idiopathic
Radiation fibrosis (lymphomas that require radiation to heart)
Amyloidosis
Sarcoidosis
Inborn errors of metabolism
Endocardial fibroelastosis
Loeffler endomyocarditis
63
Q

According to JNC 8, what are the maximum systolic and diastolic BP range goals for hypertensive pts under 60?
Over 60?

A

Age < 60 yrs old
< 140/90 mmHg

Age > 60 yrs old
< 150/90 mmHg

64
Q

List the non-pharmacological therapies for ACUTE CHF.

A

PCI
Ultrafiltration
Intra-aortic balloon pump
LVADs

65
Q

Statin effects on % reductions/increases of serum lipids:

A

v LDL (20-60%), v TG (10-20%), ^ HDL (5-10%)

66
Q

Read everything important about Kawasaki Disease.

A
  • AKA mucocutaneous lymph node syndrome
  • Typically azn children <4
  • Nonspecific signs: fever, conjunctivitis, erythema to palms/soles, enlarged cervical nodes, strawberry tongue, desquamation
  • *Coronary a. commonly involved: risk for thrombosis w/MI; aneurysm w/rupture
  • CBC, ESR, CRP, LFT, albumin (show inflam.), echo
  • Similar to PAN- less severe fibrosis
  • Likely microbial agent cause; self-limited
  • Tx: ASA + IV IG (but never give child w/viral syndrome ASA)
67
Q

How does Niacin act?

A

A. Decreased lipolysis in adipocytes –> decreased FFA –> decreased VLDL.
B. Inhibits DGAT2 –> decreased VLDL synthesis.
C. Reduces hepatic ApoCIII (LDL inhibitor) –> increased LPL –> increased VLDL clearance.
D. Increased apoAI expression –> increased HDL production.
E. Decreased Lp(a) –> decreased thrombosis.

68
Q

Name the first-line DOC’s for HTN.

A
  • Diuretics
  • CCBs
  • ACEIs/ARBs
69
Q

Pts w/what dz should not take acetazolamide?

A

Cirrhosis (increased urine pH reduces NH3 secretion and thereby increases serum NH3)

70
Q

If aortic stenosis occurs in a pt age 45-50 in the U.S., you should first think what?

A

Bicuspid valve.

71
Q

Name the 2 medium vessel vasculides and their differentiating factors.

A
  1. Polyarteritis nodosa: GI, hep. B

2. Kawasaki disease: kids, heart

72
Q

3 sequelae from calcific aortic stenosis?

A
  • CHF
  • Ischemia
  • Syncope
73
Q

Name the cardioselective BBs.
- Which is lipophilic?

Name the non-selective BBs.
- Which has longer T1/2, and which is used to treat rebound tachy w/hypotensive meds?

Which is a partial non-selective BB?

Name the BBs w/some alpha-blocking activity. Which is lipophilic (given IV), and which is a vasodilator?

A

(A-M): atenolol, metoprolol (lipo, so sympatholytic)

Propranolol (tx of tachy), nadolol (longer T1/2)

Pindolol

Labetolol (lipophilic, IV), carvedilol (vasodilator)

74
Q

Good Combo’s for treating HTN: (may be >1 answer for some)

  • Thiazide or Loop diuretic with _________________.
  • Thiazide diuretic with _________________.
  • CCBs with ___________________.
A
  • K+-sparing diuretics
  • Beta-blockers; ACEIs, ARBs (CCB too?)
  • ACE-inhibitors, ARBs
75
Q

3 types of tissue found in heart valves?

A
  • Spongiosa: more matrix and GAGs
  • Fibrosa: mostly fibrosis
  • Reticularis: more elastic fibers
76
Q

What is PCSK9?

A

Protease, produced by the liver, that leads to the degradation of hepatocyte LDL receptors. Inhibited by PCSK9 inhibitors evolocumab, alirocumab.

77
Q

What comprises ACS?

A

Unstable angina
nonSTEMI
STEMI

78
Q

Most common cause of myocarditis in US?

A

Coxsakie A & B viruses
(also cytomegalovirus, HIV, bacteria, parasites)
- There is also immune-mediated (drug rxns, rheumatic fever), giant cell myocarditis, and sarcoidosis (noncaseating granulomas)

79
Q

What is congo red staining used to see?

A

Beta-amyloid (apple-green birefringence under polarized light)

80
Q

What is the “triad” of areas that small vessel vasculides typically affect?

A

Skin, lung, kidneys

81
Q

Cutoff for hypertensive urgency/emergency, in mmHg?

A

> 180/120

200 is # he had for malignant

82
Q

Niacin’s effects on % reductions/increases of serum lipids:

A

Effect on serum lipids: v TG (30-80%), v LDL (10-20%), ^ HDL (10-30%)

83
Q

Name the 2 large vessel vasculides and their differentiating factors.

A
  1. Temporal/Giant Cell Arteritis: > 50 y/o

2. Takayasu Arteritis: Adults < 50 y/o

84
Q
  1. Which thiazide is 1/10th the potency of HCTZ?
  2. 10x more potent than HCTZ?
  3. 20x more potent than HCTZ, but T1/2 10-22 hrs?
  4. Same potency as HCTZ, but T1/2 44 hrs (longer duration), may be more effective?
A
  1. Chlorothiazide
  2. *Metolazone
  3. Indapamide
  4. Chlorthalidone
85
Q

What anti-hypertensives would you recommend to a pt with DM?

A
  • ACE inhibitors
  • CCBs
    few effects on carb metabolism
86
Q

Name the contraindications for each diuretic:

  1. Thiazides
  2. Loops
  3. K+ sparing
A
  1. NSAIDs, beta-blocks (raises LDL/HDL ratio)
  2. NSAIDs, aminoglycosides
  3. NSAIDs, ARBs, ACEIs (RAS inhibitors)
87
Q

Name the acquired clotting factor abnormalities for your bleeding differential.

A
  1. Vit K deficiency
  2. Factor inhibitors
  3. Liver failure
  4. Drugs
  5. DIC
88
Q

What drugs do you give for any ACS?

A
  1. Anticoagulant (eg heparin)
  2. Antiplatelets (eg ASA + ADP receptor inhibitor)
  3. BBs
  4. ACEIs
  5. Statins
    (Sx control w/NTG + morphine)