Cutaneous paraneoplastic phenomena

Question 1

What are genodermatoses?

Answer 1

Genetic diseases which carry an increased risk of internal malignancy and skin signs as part of the syndrome

Question 2

Give 5 examples of genodermatoses.

Answer 2

Birt-Hogg-Dube syndrome
Lynch syndrome
MEN type 2B
Neurofibromatosis
Peutz-Jeghers syndrome
Gardner syndrome
Gorlin syndrome (basal cell naevus syndrome)
Progeria

Question 3

What types of lesions can paraneoplastic syndromes produce?

Answer 3

Papulosquamous e.g. acanthosis nigricans, Sign of Leser-Trelat, extramammary Paget disease, acquired ichthyosis

Erythematous e.g. dermatomyositis, acuet febrile neutrophilic dermatosis, hypertrophic osteoarthropathy and digital clubbing, necrolytic migratory erythema.

Bullous e.g. paraneoplastic pemphigus

Miscellaneous e.g. carcinoid syndrome, granulomatous dermatitis, hypertrichosis lanuginosa acquisita, cancer itch, Trousseau syndrome

Question 4

What is shown?

Answer 4

Gottron papules - dermatomyositis

Question 5

What is shown?

Answer 5

Cowden disease