Cutaneous Manifestations of Systemic Disease - Malignancy Flashcards
What cancer is associated with pruritus?
Hodgkin’s lymphoma
What cancer is associated with cutaneous metastases (pale to purple nodules on the head and neck)?
WOMEN: Breast and Colon cancer
MEN: Lung and Colon cancer
What cancer is associated with unilateral eczematous changes to the nipple?
What dermatological condition is this referring to?
Breast cancer
Paget’s disease of the nipple/areola
What diagnosis is associated with extramammary Paget’s disease?
Gastrointestinal cancers
What cancer is associated with acanthosis nigricans?
What histological findings are associated with it?
Adenocarcinoma, especially of the GI tract (also breast)
thickening of the squamous layer of the epidermis (thickened stratum corneum with dermal projections but NO increase in melanin)
What genetic marker is associated with Sweet syndrome?
What cancers is Sweet syndrome associated with?
HLA B54
AML (acute myelocytic leukemia)
Colon cancer
Breast cancer
GU tract cancer
What other dermatological condition can Sweet syndrome look like?
What histological findings are seen?
Erythema multiforme
Heavy neutrophilic infiltrate throughout the dermis (starts in dermis and goes up to epidermis)
What cancer is associated with primary amyloidosis?
What are 3 signs/symptoms of this primary amyloidosis?
What type of histological stain is required for diagnosis?
Multiple myeloma
- Macroglossia
- Purpuric/ecchymotic papules on eyelids and limbs, increased blood vessel fragility
Congo red stain
Where is the mutation in familial amyloidosis?
TTR gene (transthyretin) on chromosome 5
What is the most common form of systemic amyloidosis?
Which 2 diagnoses is secondary amyloidosis seen with?
What organs are the most affected?
Amyloid A amyloidosis
- Rhematoid arthritis
- Osteomyelitis
- Spleen
- Liver
- Kidney
What cancer is this associated with?
What is the skin manifestation called?
What laboratory finding is associated with this diagnosis?
50% of cases are lung cancer
Erythema gyratum repens
Peripheral eosinophilia
What is this diagnosis?
Where is it located?
What happens when it dissipates?
What type of cancer is it associated with?
Necrolytic migratory erythema
genital/anal, groins, legs, perioral
Leaves a brown mark
alpha-cell tumour of the pancreatic islet (glucagonoma)
What is this diagnosis?
What gene is it associated with?
What types of cancers are associated with it?
What are other associations?
Cowden’s syndrome
PTEN mutation
Breast cancer, Thyroid cancer
- Endometriosis
- Fibrocystic disease of the breast
- Intellectual disability
- Macrocephaly
What cancers are dermatomyositis associated with?
Adenocarcinoma of the breast, GI tract or Lung
What cancers can leukoclastic vasculitis be associated with in adults?
Lymphoma
Solid tumours
