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UCD Dermatology - Term 2 > Cutaneous Manifestations of Systemic Disease > Flashcards

Cutaneous Manifestations of Systemic Disease Flashcards

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Dermatology Board Prep flashcards
1
Q

What cancer is associated with pruritus?

A

Hodgkin’s Lymphoma

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2
Q

List 5 causes of pruritus

A
  1. Pemphigoid prodrome
  2. Hodgkin’s lymphoma
  3. Erythropoietic protoporphyria (EPP) with exposure to sunlight
  4. Psychogenic (parasitophobia)
  5. Drug-induced (allopurinol, statins, opioids, amiodarone)
  6. Elevated estrogen (pregnancy)
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3
Q

What diagnosis is associated with fluorescing RBCs?

A

Porphyria

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4
Q

What virus is associated with erythema multiforme?

A

HSV

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5
Q

What is the most common initial rash presentation of a rheumatic or autoimmune disease?

A

Non-specific rash

(some form of erythema)

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6
Q

List 3 dermatological manifestations of SLE

A
  1. Alopecia
  2. Photosensitive rash with butterfly distribution on face
  3. Periungual telangiectasia
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7
Q

What are these 2 dermatological findings?

A

LEFT: Photosensitive rash with butterfly distribution

RIGHT: periungual telangiectasia

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8
Q

List 4 dermatological findings with systemic sclerosis

A
  1. Hard and sclerotic skin
  2. Microstomia
  3. Sclerodactyly
  4. Telangiectasias
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9
Q

What finding can confirm SLE with histology?

A

Direct Immunofluorescence

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10
Q

What finding is seen on histology of systemic sclerosis?

A

Greatly thickened collagen

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11
Q

What systems are primarily affected in systemic sclerosis?

What investigation can you order to help with investigations?

A
  • Lungs
  • GI tract
  • Heart
  • Kidneys
  • Pulmonary Function Tests
  • CT scan
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12
Q

What are these 2 dermatological findings?

A

LEFT: Microstomia

RIGHT: Sclerodactyly (tapered fingers)

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13
Q

List 5 dermatological findings in dermatomyositis

A
  1. Shawl sign
  2. Heliotrope rash
  3. Periorbital edema
  4. Periungual telangiectasia
  5. Ragged cuticles
  6. Proximal muscle weakness
  7. Gottron’s papules
  8. “Mechanics” hands
  9. Calcification of skin (juvenile form)
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14
Q

What cancer is associated with dermatomyositis?

A

Adenocarcinoma of breast, lung or GI tract

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15
Q

What antibodies are positive in dermatomyositis?

List 2 other confirmatory tests

A

+Jo antibodies

  • Elevated CK
  • EMG
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16
Q

What types of infection commonly are associated with Reiter’s syndrome?

What are the 3 diagnostic findings?

What dermatological manifestation is seen?

What is a common association?

A

GI tract or GU (especially Chlamydia infections)

Conjunctivitis, Arthritis, Urethritis

Keratoderma blenorrhagica

HLA B27

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17
Q

What is this dermatological condition?

A

Keratoderma blenorrhagica

18
Q

List 3 skin manifestations seen with sarcoidosis

A
  1. Erythema nodosum
  2. Annular, papules and plaques (granulomatous on histology)
  3. Lupus pernio
19
Q

What systems are involved in sarcoidosis?

A
  • Lungs
  • Joints
  • Skin
  • Eyes (slit lamp examination)
20
Q

What is the classic type of lesion for sarcoidosis?

A

Plaques with no scale

There is a papular type of sarcoid - annular sarcoid

21
Q

What are associations with yellow nail syndrome?

A
  • Chronic lymphedema
  • Unpleasant cough (productive, rattly)

Primarily a lymphatic drainage problem

Associated with middle age

22
Q

What bacteria is commonly associated with HSP?

A

Streptococcus

23
Q

What histological findings are seen with leukoclastic vasculitis?

A
  • Nuclear dust
  • Inflammation of blood vessels with leaking
  • Direct immunofluorescence helps with diagnosis
24
Q

What are 2 diagnoses associated with mottling of the lower extremities?

A
  • Polyarteritis nodosa
  • Livedo reticularis
  • Livddo racemosa
25
Q

What is this dermatological finding?

A

Pseudoxanthoma elasticum

26
Q

Where is pseudoxanthoma elasticum seen?

What inheritance is seen with it?

What causes it?

What are associated complications?

A

Flexural areas

Autosomal recessive or spontaneous

Defect in elastic fibres

Angioid streaks in retina, hypertension, PVD/CAD

27
Q

Name this finding

A

Angioid streaks

28
Q

Name 5 findings associated with LEOPARD syndrome

A

Autosomal dominant

  • Lentigines
  • ECG changes
  • Ocular
  • Pulmonary stenosis
  • Abnormal genitalia
  • Retarded growth
  • Deafness
29
Q

What is Carney complex associated with?

Name the 2 syndromes associated with it.

A

Endocrine overactivity (Cushing’s)

LAMB

  • Lentigines
  • Atrial Myxoma
  • Blue nevi

NAME

  • Nevi
  • Atrial Myxoma
  • Myxoid neurofibroma
  • Ephelides
30
Q

What is associated with Peutz-Jegher syndrome?

What dermatological findings are found with this disorder?

A

15 X risk of cancer than average person

Lentigines (periorbital, dorsum of hands, mucosa), hamartomas (gastric polyps) in GI tract

31
Q

What dermatological findings are associated with HHT (hereditary hemorrhagic telangiectasia) aka Osler Weber Rendu syndrome

A

Telangiectasia on skin and oral mucosa

Recurrent epistaxis

Hemorrhage from any area (skin, lungs, brain, liver, eyes, GI tract)

32
Q

What is the triad associated with acrodermatitis enteropathica?

A
  • Bullae and pustules, acral and periorificial distribution
  • Diarrhea
  • Alopecia
33
Q

List 4 dermatological manifestations associated with diabetes

A
  1. Diabetic dermopathy
  2. Granuloma annulare
  3. Necrobiosis lipoidica diabeticorum
  4. Eruptive xanthoma
  5. Vascular - small vessel disease (peripheral) - ulceration/gangrene
34
Q

What is this dermatological diagnosis?

A

Diabetic Dermopathy

35
Q

What is this dermatological diagnosis?

What timing is it associated with?

A

Granuloma Annulare

At time of diagnosis of diabetes

36
Q

What is this dermatological diagnosis?

When is it commonly seen?

A

Necrobiosis lipoidica diabeticorum

At the time of diagnosis

37
Q

What is this dermatological condition?

What laboratory abnormalities are associated with this finding?

A

Eruptive xanthomata

Hypertriglyceridemia or hyperlipidemia

38
Q

What is the diagnosis?

A

Hereditary Hemorrhagic Telangiectasia

39
Q

What is the diagnosis?

A

Acrodermatitis enteropathica

40
Q

What is the diagnosis?

A

Peutz Jegher syndrome

41
Q
A

UCD Dermatology - Term 2 (14 decks)

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