cushing's disease 1/6

Question 1

What are symptoms of Cushing’s disease

Answer 1

hallmark:
- weight gain
- purple striae, pink or purple stretch marks
- ruddy complexion
other:
- Fatigue, depression, emotional lability, mental changes
- Excessive hair growth
- Bruising
- Proximal muscle weakness
- hypertension

Question 2

What is and what causes cushing’s disease?

Answer 2

elevated cortisol levels due to

• Endogenous over production of cortisol
• Exogneous use of corticosteroids

Question 3

How is Cushing’s disease diagnosed?

Answer 3

Laboratory analysis of cortisol levels in urine, saliva, or blood

Question 4

most common endogenous etiology of cushing’s disease?

Answer 4

• benign tumor in pituitary gland- increase in the secretion of adrenocorticotropic hormone ACTH causes increased cortisol production
• benign tumor in adrenal gland - increase level cortisol
  other: malignancy, genetics

Question 5

most common exogenous etiology of cushing’s disease?

Answer 5

High doses of glucocorticoids for inflammatory conditions

Question 6

Where does weight gain a occur in cushing’s disease?

Answer 6

face - moon face
upper back - buffalo hump
supraclavicular
midsection - central obesity

Question 7

cushing’s disease gender preference and age of onset

Answer 7

female

onset 25-40year old

Question 8

what is cortisol

Answer 8

Glucocorticoid hormone produced by adrenal cortex of kidneys

Assists in regulation of cardiovascular function, metabolism, and main stress hormone