Curs 4- Eritrocitele

Question 1

De unde provine energia E

Answer 1

glicoliza anaeroba

Question 2

Glicoforinele

Answer 2

prot integrala de memb, nr grupari de acid salicilic

sunt receptori pentru paraziti - plasmodium falciparum

Question 3

Proteine ale citoscheletului

Answer 3

spectrina, actina, ankirina, aducina

Question 4

Spectrina

Answer 4

50-75% din masa citoscheletului, formeaza o retea ancorata la membr cel prin ankirina si aducina>
Participa la forma si elasticitatea E

Question 5

Glutation

Answer 5

generat in cuursul suntului hexozo-monofosfat

Question 6

Glutation rol

Answer 6

prevenirea oxidarii Hb si a unor structuri critice ale E, de membrana sau ale citoscheletului

Question 7

Methemoglobin reductaza

Answer 7

reduce fierul oxidat din strct HB la fier feros

Question 8

Anhidraza carbonica

Answer 8

sustine formarea de bicarbonat din CO2 la niv tisular de catre E

Question 9

2,3 DPG

Answer 9

scade afinitatea HB pt O2-> curba de disociere a Hb se depl la dreapta

Question 10

Hemoglobina

Answer 10

fixeaza aproape toata cant de O2, o parte de CO2 si mentine ph la val norm

Question 11

Concentratia Hb

Answer 11

f: 14-16 g/dl
m: 15-17 g/dl

Question 12

Combinatii fiziologice ale Hb

Answer 12

cu O2- oxiHb
cu CO2- carbaminoHb
Hb redusa - dupa cedarea O2

Question 13

Cianoza

Answer 13

c% Hb reduse >5g/dl => coloratie albastruie a mucoaselor si tegumentului

Question 14

Combinatii patologice ale Hb

Answer 14

methHb, carboxiHb, HbS, Hb instabila, Hb cu afinitate anormala pt O2

Question 15

Cauza methHb

Answer 15

defect genetic ale methHb reductazei sau actiunii unor ag oxidanti asupra hb normale (nitrati, nitriti, anilina, nitrobenzen, medicamente)

Question 16

Anemie drepanocitara

Answer 16

inlocuirea ac glutamic cu valina in poz 7 a lantului beta al Hb ==> HbS, instabila, E ia forma de secera

Question 17

Hb instabile

Answer 17

mutatii genetice care scat solobulitatea Hb in mediul intracel

Question 18

Prop eritrocite

Answer 18

1. Indicii eritrocitari
2. Elasticitae
3. Permeab selectiva a membr
4. Rezistenta globulara
5. Solubilitatea in suspensie
6. Antigenicitatea

Question 19

Permeab selectiva a membr

Answer 19

impermeabila: cationii mono si divalenti
permeabila: apa, anioni, uree

Question 20

VSH

Answer 20

f: 10-16 mm/1h
m: 6-8 mm/1h