Curs 2- plasma

Question 1

cine contribuie la osmolaritatea plasmei

Answer 1

Na, anionii, glucoza, specii azotate neproteice

Question 2

Proteom

Answer 2

totalitatea proteinelor plasmatice

Question 3

Proteinemie

Answer 3

concentratia plasmatica a proteinelor

Question 4

Euproteinemia

Answer 4

6.5-8g/dl

Question 5

Roluri generale proteine plasmatice

Answer 5

1. Mentin vol plasm si contribuie la repartitia apei intre compartimente- pcOsm
2. Mentin ph sg
3. Transporta- lipide, me grele, ioni, bilirubina, hormoni lipidici, medicamente
4. Coagulare/fibrinoliza
5. Aparare - igg, lizozim, prot complement, lactoferina
6. Genereaza vascozitatea sg
7. Sursa de aa
8. Enzime- gamaglutamilgransferaza, lizozim

Question 6

Fractiuni proteice - electroforeza

Answer 6

albumina 56-60%
alfa1 globuline 3-5%
alfa2 globuline 6-8%
beta globuline 10-14%
gamma globuline 16-20%

Question 7

Rol albumina

Answer 7

ment pres colo-osm, volum plasm
trasnport (bilirubina, medicamente, metale grele)
sursa de aa

Question 8

Proteine de faza acuta

Answer 8

proteina C reactiva, fibrinogen, lectina, comp sist complement, ceruloplasmina, haptoglobina, hepcidina, peptidul corelat cu gena calcitoninei

Question 9

Sisteme proteazice plasmatice

Answer 9

al coagularii, fibrinolizei, complement, kininoformator

Question 10

Antiproteaze plasmatice

Answer 10

alfa1 antitripsina- inhiba tripsina si elastaza leucocitara

alfa 2 macroglobulina- inhiba factorii activati ai coagularii, plasmina, elastaza leucocitara si colagenaza

Question 11

Transferina

Answer 11

electroforetice beta, preia Fe si il transporta

Question 12

Ceruloplasmina

Answer 12

alfa2 globulina, fixeaza si transp Cu

Question 13

Gammaglob

Answer 13

aparare imuna

Question 14

Haptoglobina

Answer 14

alfa2 globulina, fixeaza Hb libera in plasma

Question 15

Plasmafereza

Answer 15

purificarea sg de anticorpi din plasma

Question 16

Principalele prod proteice utilizate in clinica

Answer 16

serul uman, albumina, gammaglob

Question 17

Comp plasmatici anorganici

Answer 17

Na, K, Mg, Ca
Cl,PO4-,HCO3-
Fe, Cu, I, Zn, Se