CSP Antibodies Revision Flashcards
1
Q
Peptidoglycan Synthesis (cell wall synthesis)
A
GLYCOPEPTIDES
- vancomycin
- bacitracin
2
Q
Folic Acid Synthesis and reduction (DNA methylation)
A
SULFONAMIDES
TRIMETHOPRIM
3
Q
Peptidoglycan Cross Linking (cell wall synthesis)
A
CARBAPENEMS MONOBACTAMS ANTIPSEUODMONAL CEPHALOSPORINS PENICILLINS
4
Q
DNA Integrity (via free radicals)
A
Metronidazole
5
Q
mRNA Synthesis (RNA polymerase)
A
Rifampicin
6
Q
Gyrase
A
FLUOROQUINOLONES - ciprofloxacin - levofloaxacin QUINOLONE - nalidixic acid
7
Q
PROTEIN SYNTHESIS
A
50S SUBUNIT
- chloramphenicol
- clindamycin
- linezolid
- macrolides = erythromycin, clarithro, azithro
- streptogramins = quinupristin, dalfoprisitn
30S SUBUNIT
- aminoglycosides = gentamycin, neomycin, amikacin, streptomycin
- tetracycline (doxy, mino)
- glycylcyline
8
Q
Fluoroquinolones
A
- oral
- inhibit DNA gyrase via topoisomerase II)
- ciprofloxacin, levofloxacin
- for gram -ve
- only oral anti-pseudomonal
- can cause C. difficile and tendonitis
9
Q
Aminoglycosides
A
- 30S subunit protein synthesis
- gentamicin, streptomycin, amikacin
- IV
- SE = ototoxicity, nephrotoxicity
10
Q
Tetracyclines
A
- 30S subunit protein synthesis
- oral or IV
- tetracycline, doxycycline
- SE = photosensitivity
11
Q
Macrolides
A
- 50S subunit protein synthesis
- oral or IV
- clarithromycin, azithromycin, erythromycin
- SE = QT prolongation
12
Q
Lincosamides
A
- 50S subunit protein synthesis
- clindamycin, lincomycin
- SE = C difficile
13
Q
Beta Lactams
A
- cell wall synthesis
- penicillin
- cephalosporins
- carbapenems
14
Q
Penicillin
A
- cell wall synth
- IV or oral
- amoxicillin, flucloxacillin, piperacillin
- more effective with beta lactamase inhibitors which inhibit bacterial breakdown of penicillin’s
- SE = allergies, cholestasis (amox), hypernatremia (pipera)
15
Q
Cephalosporins
A
- IV
- cell wall synth
- cefuroxime
- ceftriaxone
- SE = C difficile
