CSF Flashcards

1
Q

where is CSF produced

A

choroid plexus

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2
Q

how much CSF is produced per hour in an adult

a. 10 mL
b. 15 mL
c. 20 mL
d. 25 mL

A

20 mL

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3
Q

T or F. CSF resembles the plasma ultrafiltrate

A

false

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4
Q

CSF

tube 1 is for:

A

chemistry and serology

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5
Q

CSF

tube 2 is for:

A

microbiology

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6
Q

CSF

tube 3 is for:

A

CM/hematology/cell counting

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7
Q

CSF

tube 4 is for:

A

additional chemistry/serology/microbiology

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8
Q

if testing will be delayed:

tube 1 should be stored at:

A

frozen temp

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9
Q

if testing will be delayed:

tube 2 should be stored at:

A

room temp

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10
Q

if testing will be delayed:

tube 3 should be stored at:

A

refrigerated temp

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11
Q

if only 1 CSF tube can be collected, what test should be prioritized?

A

microbiology

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12
Q

CSF appearance:

hazy, turbid, milky

A

microbes, protein

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13
Q

CSF appearance:

oily

A

radiographic contrast media

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14
Q

CSF appearance:

bloody

A

traumatic tap, rbcs

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15
Q

CSF appearance:

xanthochromic

A

hemorrhage, bilirubin, hemoglobin, carotene

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16
Q

CSF appearance:

clotted

A

BBB disorders, fibrinogen

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17
Q

CSF appearance:

pellicle

A

BBB disorders, tubercle meningitis, clotting factors

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18
Q

differentiate intracranial hemorrhage vs traumatic tap

A

traumatic tap - uneven blood distribution, has clot, not xanthochromic

19
Q

when is the time RBC count is done in CSF?

A

to correct WBC count because of traumatic tap

20
Q

T or F. CSF should be diluted first whether it is turbid or clear

A

False. if the sample is clear, no need for dilution

21
Q

counting area for WBC count

A

4 WBC squares

22
Q

CSF WBC proportion in adults

A

lymph 30

mono 70

23
Q

CSF WBC proportion in children

A

lymph 70

mono 30

24
Q

term for increased mononuclear count

A

pleocytosis

25
Q

condition associated with pleocytosis with increased neutrophils

A

bacterial meningitis

26
Q

condition associated with moderate pleocytosis with increased mononuclears

A

viral, tubercular, fungal, or parasitic meningitis

27
Q

what type of WBC is seen in CSF if the patient has infection from Coccidioides immitis?

A

eosinophil

28
Q

this WBC indicates previous hemorrhage

A

macrophage

29
Q

these are degraded phagocytosed RBCs; stains dark-blue or black granules

A

hemosiderin granules

30
Q

further degradation product, iron free

A

hematoidin crystals

31
Q

cells that are seen in the epithelial lining of choroid plexus, no nucleoli

A

choroidal cells

32
Q

seen in the lining of ventricles and neural canal, seen in clusters

A

ependymal cells

33
Q

seen in the lining cells of arachnoid, also seen in systemic malignancies

A

spindle-shaped cells

34
Q

these cells indicate dissemination from lymphoid tissues due to complication of acute leukemia

A

lymphoma cells

35
Q

most frequently performed chemical test for the differentiation of meningitis

A

CSF protein

36
Q

when CSF protein is higher than glucose, what kind of meningitis is present?

A

bacterial

37
Q

CSF protein NV

a. 35-55
b. 30-50
c. 15-45
d. 5-15

A

15-45

38
Q

most abundant protein in CSF

A

albumin

39
Q

second most abundant protein in CSF

A

prealbumin

40
Q

two methods of CSF protein measurement

A
  • nephelometry

- dye-binding

41
Q

protein that is solely found in CSF

A

tau transferrin

42
Q

to determine whether IgG production is
within CNS or due to damaged
blood-brain barrier

A

IgG index

43
Q

indicates recent destruction of myelin

sheath (demyelination)

A

myelin basic protein