CSF Flashcards
where is CSF produced
choroid plexus
how much CSF is produced per hour in an adult
a. 10 mL
b. 15 mL
c. 20 mL
d. 25 mL
20 mL
T or F. CSF resembles the plasma ultrafiltrate
false
CSF
tube 1 is for:
chemistry and serology
CSF
tube 2 is for:
microbiology
CSF
tube 3 is for:
CM/hematology/cell counting
CSF
tube 4 is for:
additional chemistry/serology/microbiology
if testing will be delayed:
tube 1 should be stored at:
frozen temp
if testing will be delayed:
tube 2 should be stored at:
room temp
if testing will be delayed:
tube 3 should be stored at:
refrigerated temp
if only 1 CSF tube can be collected, what test should be prioritized?
microbiology
CSF appearance:
hazy, turbid, milky
microbes, protein
CSF appearance:
oily
radiographic contrast media
CSF appearance:
bloody
traumatic tap, rbcs
CSF appearance:
xanthochromic
hemorrhage, bilirubin, hemoglobin, carotene
CSF appearance:
clotted
BBB disorders, fibrinogen
CSF appearance:
pellicle
BBB disorders, tubercle meningitis, clotting factors
differentiate intracranial hemorrhage vs traumatic tap
traumatic tap - uneven blood distribution, has clot, not xanthochromic
when is the time RBC count is done in CSF?
to correct WBC count because of traumatic tap
T or F. CSF should be diluted first whether it is turbid or clear
False. if the sample is clear, no need for dilution
counting area for WBC count
4 WBC squares
CSF WBC proportion in adults
lymph 30
mono 70
CSF WBC proportion in children
lymph 70
mono 30
term for increased mononuclear count
pleocytosis
condition associated with pleocytosis with increased neutrophils
bacterial meningitis
condition associated with moderate pleocytosis with increased mononuclears
viral, tubercular, fungal, or parasitic meningitis
what type of WBC is seen in CSF if the patient has infection from Coccidioides immitis?
eosinophil
this WBC indicates previous hemorrhage
macrophage
these are degraded phagocytosed RBCs; stains dark-blue or black granules
hemosiderin granules
further degradation product, iron free
hematoidin crystals
cells that are seen in the epithelial lining of choroid plexus, no nucleoli
choroidal cells
seen in the lining of ventricles and neural canal, seen in clusters
ependymal cells
seen in the lining cells of arachnoid, also seen in systemic malignancies
spindle-shaped cells
these cells indicate dissemination from lymphoid tissues due to complication of acute leukemia
lymphoma cells
most frequently performed chemical test for the differentiation of meningitis
CSF protein
when CSF protein is higher than glucose, what kind of meningitis is present?
bacterial
CSF protein NV
a. 35-55
b. 30-50
c. 15-45
d. 5-15
15-45
most abundant protein in CSF
albumin
second most abundant protein in CSF
prealbumin
two methods of CSF protein measurement
- nephelometry
- dye-binding
protein that is solely found in CSF
tau transferrin
to determine whether IgG production is
within CNS or due to damaged
blood-brain barrier
IgG index
indicates recent destruction of myelin
sheath (demyelination)
myelin basic protein
