cryoglobinemic vasculitis

Question 1

who gets

Answer 1

90% of cases are associated with hep C infections. IV drug users are at major risk.

Question 2

cryoglobins

Answer 2

cold antibodies. they precipitate in the cold but redissolve when warmed.

Question 3

type I clonality

Answer 3

monoclonal

Question 4

type I rheumatoid factor?

Answer 4

none.

Question 5

associated diseases with type I

Answer 5

multiple myeloma, wldenstroms macroglobinemia, lymphoma

Question 6

symptoms of type I

Answer 6

usually asymptomatic until the antibody concentration causes hyper viscosity syndrome.

Question 7

type II clonality

Answer 7

monoclonal

Question 8

type III clonality

Answer 8

polyclonal

Question 9

Type II and III rheumatoid factors

Answer 9

yes

Question 10

type II associated and presentation

Answer 10

Lymphoproliferative diseases, rheumatic disease, chronic infection, presents as vasculitis, lower extremity purpura, glomerulonephritis, and peripheral neuropathy.
90% associated with HCV infection

Question 11

type III association and presentation

Answer 11

Rheumatic diseases and chronic infections. Presents as vasculitis. Lower extremity purpura, glomerulonephritis and peripheral neuropathy. 90% associated with HCV infection

Question 12

treat

Answer 12

if hyper viscosity is present then plasmapheresis is necessary, with chemotherapy to treat the malignancy. otherwise prednisone cyclophosphamide or both.