Critical Care/Nutrition Flashcards
Negative property of elemental tube feed formulas
Hyperosmolar
Amino acid formula for someone with hepatic dysfunction limits these
Aromatic amino acids and methionine. Have higher concentration of branched chain amino acids
Essential fatty acid deficiency symptoms
Waxy skin, dermatitis, thrombocytopenia
Secondary active transport (relying on sodium gradient for transport) describes absorption of what molecules in intestine
glucose and galactose
Difference between marasmus and kwashiokor
Kwashiokor has edema and anasarca
B12 deficiency (usually associated with loss of intrinsic factor from gastrectomy, or resection of terminal ileum) symptoms
beefy tongue, megaloblastic anemia, neuropathy, hypercoagulability
Zinc deficiency symptoms
rash and hair loss
Chromium deficiency symptoms
hyperglycemia
Pantothenic acid deficiency
burning feet
Biotin deficiency
AMS, dermatitis, anorexia, myalgia
Niacin (B3) deficiency
Dermatitis (areas exposed to sun), diarrhea, dysphagia (due to ulcers, sores), dementia
Thiamine (B1) deficiency
Beri beri (wet) - heart failure; Wernicke encephalopathy ( nystagmus, ataxia) confusion, or coma
Vitamin E deficiency
Peripheral neuropathy, ataxia
Vitamin deficiency associated with carcinoid syndrome (tryptophan metabolized to serotonin instead of this)
Niacin (get pellagra)
Common TPN formulations
25% or 50% dextrose, 1.5 g/kg/day protein, 10% to 20% lipid emulsion, 30 cc/kg fluid admin
Omega 3 and omega 6 fatty acids are mono or poly unsaturated
poly
Prealbumin half life
2-3 days
transferrin half life
8-10 days
albumin half life
20 days
Direct thrombin inhibitors and approximate half life
Dabigatran (Pradaxa) - 12 hours
Bivalirudin - 20-30 min
Argatroban - < 1 hour
3 methods drugs have to inhibit platelet aggregation
ADP receptor
Thromboxane A2
Glycoprotein (G2b3a) receptor
4 ADP receptor (P2Y12) blockers (reversible or irreversible)
Clopridurgrel (Plavix) (irreversible)
Prasugrel (Effient) (irreversible)
Ticagrelor (Brilinta) (reversible)
Cangreglor (reversible)
Type I vWD
partial deficit; treat w desmopression or cryoprecipitate
Type II vWD
Qualitative defect; treat w cryoprecipitate
Type III vWD
Complete deficit; treat w cryoprecipitate
Drug used to treat AVMs
thalidomide
Initial dose of flumanezil for benzo overdose
0.2 mg IV
Contraindications for ketamine use
myocardial ischemia; gluacoma
Brooke formula for burn resuscitation
2 cc/kg/TBSA over 24 hours with 1/2 in first 8 hours (titrated to UOP 0.5-1 cc/kg/hr)
Rule of 10s for burn resuscitation
10 x TBSA for 24 hours with 1/2 in first 8 hours
Indications for ICP monitoring
GCS 8 or less with abnormal head CT
normal head CT with 2 of : age > 40, hypotension, posturing.
LR is …
Na 130, K 4, Cl 109, ca 2.7, lactate 28
Output from Saliva stomach small bowel biliary pancreas
1.5L 1-2L 1.5L 500 cc 1.5 L
(small bowel reabsorbs > 8L)
winters forumla
expected Pco2 = 1.5 x serum bicarb + 8
free water deficit
sodium - 140/140 x total body water