Critical Care and Med MGMT

Question 1

Withdrawal Syndrome Drugs

Answer 1

Beta blockers, clonidine, BNZ, SSRIs, baclofen

Question 2

Propylene Glycol Toxicity

Answer 2

Assoc w/ hyperosmolar anion gap metabolic acidosis, renal dysfunction, hemolysis, arrhythmias, and seizure

Question 3

Drug with High Propylen Glycol Content

Answer 3

Benzo (esp lorazepam), etomidate, NTG, barbs (pheno), phenytoin

Question 4

Carbamazepine Level

Answer 4

4-12 mcg/mL

Question 5

Digoxin Level

Answer 5

Chronic HF: 0.5-9 ng/mL; A-fib: 1.5-2 ng/mL; may check a level 4 h after IV or 6 h after enteral dose

Question 6

Lidocaine Level

Answer 6

1-5 mcg/ml; check if tx last 24h or if pt has LV dysfunction or hepatic impairment

Question 7

Phenobarbital Level

Answer 7

15-40 mcg/mL

Question 8

Phenytoin Level

Answer 8

10-25 mcg/mL, 2 hr after IV load then again in 2-3 d, 4 h after IM load, adjust to low albumin an CrCl less than 10

Question 9

Theophylline Level

Answer 9

5-15 mcg/mL, 24 h after initiation of cont IV

Question 10

Valproic acid Level

Answer 10

50-100 mcg/mL