CPTP 3.4 Anti-psychotics

Question 1

Haloperidol

+ clinical use + significant side effects (if any)

Answer 1

TYPICAL ANTIPSYCHOTIC

Clinical use:
Schizo, Mania, Agitation/aggression, other psychoses

Significant side effects:
QT prolongation

Question 2

Chlorpromazine

+ clinical use + significant side effects (if any)

Answer 2

TYPICAL ANTIPSYCHOTIC

No significant side effects

Question 3

Olanzapine

+ clinical use + significant side effects (if any)

Answer 3

ATYPICAL ANTIPYSCHOTIC

Clinical use:
Often most effective first-line for psychosis,
+ Schizophrenia, bipolar, msnis

No significant side effects

Question 4

Sulpride

+ clinical use + significant side effects (if any)

Answer 4

ATYPICAL ANTIPYSCHOTIC

No significant side effects

Question 5

Aripiprazole

+ clinical use + significant side effects (if any)

Answer 5

ATYPICAL ANTIPYSCHOTIC

Side effects:
Doesn’t give side effects but no very effective

Question 6

Quetiapine

+ clinical use + significant side effects (if any)

Answer 6

ATYPICAL ANTIPYSCHOTIC

No significant side effects

Question 7

Clozapine

+ clinical use + significant side effects (if any) + cautions

Answer 7

ATYPICAL ANTIPYSCHOTIC

Clinical use:
More effective for schizophrenia than psychosis but 3rd line due to side effects
Given for resistant schizophrenia

Side effects:

• agranulocytosis/neutropenia (so only 3rd line)
• regular blood tests needed
• increased infx risk

Cautions

• in elderly, seizures
• Smoking affects dose

Question 8

Pathways affected by dopamine transmission

Answer 8

• Mesolimbic
• Mesocortical
• Nigrostriatal
• Tuberoinfundibular

Question 9

Risperidone

+ clinical use + significant side effects (if any) + cautions

Answer 9

ATYPICAL ANTIPYSCHOTIC

Clinical use: Psychosis, mania, Aggression

Side effects:
Highest risk of extrapyramidal side effects among commonly used atypical antipsychotics

Cautions:

• heart disease
• hepatic impairment