CPTP 3.16 Corticosteroids

Question 1

Hydrocortisone

Clinical use

Answer 1

• Oral
• Parental (severe acute inflammation)
• Topical (itchy skin)

Question 2

Prednisolone

Clinical use

Answer 2

-Oral (asthma, hypersensitivity severe inflammatory conditions)

Question 3

Betamethosone

Clinical use

Answer 3

• R arthritis, severe asthma, ulcerative colitis

- Many other inflammatory & autoimmune conditions

Question 4

Side effects of corticosteroids

Answer 4

• Easy bruising
• Muscle wasting, atherosclerosis
• Euphoria, depression & psychosis
• Thinning skin/poor wound healing
• Hyperglycaemia
• Osteoporosis
• Cushing’s like syndrome

Question 5

Production site + function of:

Cortisol, Aldosterone

Answer 5

CORTISOL

• pdtn in Zona fasciculata
• glucocorticoid
• modulates carbs, fat, protein metabolism

ALDOSTERONE

• pdt in Zona glomerulosa
• mineralcorticoid
• controls secretion of angiotensin II
• modulates Na/K balance