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CPTP stage 3 > CPTP 3.3 Anti-depressants > Flashcards

CPTP 3.3 Anti-depressants Flashcards

1
Q

Fluoxetine

+ clinical use + significant side effects (if any)

A

SSRI

Clinical use:
Depression (first line), Bulimia, OCD

Side effects:
usual SSRI, no significant

Note: Long half life

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2
Q

Citalopram

+ clinical use + significant side effects (if any)

A

SSRI

Clinical use:
Depression, panic disorder

Significantly more affinity for 5-HT than NA –> more useful for patients who don’t like NA side effects

Significant side effects:

  • bleeding risk
  • QT prolongation
  • Mania
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3
Q

Sertraline

+ clinical use + significant side effects (if any)

A

SSRI

Clinical use:
Depression

Side effects:
usual SSRI, no significant

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4
Q

Paroxetine

+ clinical use + significant side effects (if any)

A

SSRI

Clinical use:
Depression

Side effects:
usual SSRI, no significant

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5
Q

Trazodone

+ clinical use + significant side effects (if any)

A

SSRI

Clinical use:
Depression

Side effects:
usual SSRI, no significant

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6
Q

Escitalopram

+ clinical use + significant side effects (if any)

A

SSRI

Clinical use:
Depression

Side effects:
usual SSRI, no significant

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7
Q

Venlafaxine

+ clinical use + significant side effects (if any)

A

SNRI

Clinical use:
Depression, Generalised Anxiety Disorder, Social Anxiety Disorder

Side effects:
usual SNRI,
(contraindicated with arrhythmia)

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8
Q

Duloxetine

+ clinical use + significant side effects (if any)

A

SNRI

Clinical use:
Depression, Generalised Anxiety Disorder, Social Anxiety Disorder

Side effects:
usual SNRI,
(contraindicated with arrhythmia)

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9
Q

Reboxetine

+ clinical use + significant side effects (if any)

A

NARI

Clinical use:
Depression

Side effects:
none significant

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10
Q

Desipramine

+ clinical use + significant side effects (if any)

A

NARI

Clinical use:
Depression

Side effects:
none significant

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11
Q

Amitriptyline

+ clinical use + significant side effects (if any)

A

TCA

Clinical use:
Severe, treatment resistant depression

Side effects:
Cardiotoxic (potentially fatal in overdose)

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12
Q

Imipramine

+ clinical use + significant side effects (if any)

A

TCA

Clinical use:
Severe, treatment resistant depression

Side effects:
Cardiotoxic (potentially fatal in overdose)

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13
Q

Lofepramine

+ clinical use + significant side effects (if any)

A

TCA

Clinical use:
Severe, treatment resistant depression

Side effects:
Cardiotoxic (potentially fatal in overdose)

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14
Q

Desipramine

+ clinical use + significant side effects (if any)

A

TCA

Clinical use:
Severe, treatment resistant depression

Side effects:
Cardiotoxic (potentially fatal in overdose)

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15
Q

Buproprion

A

Dopamine reuptake inhibitor

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16
Q

Phenelzine

+ clinical use + significant side effects (if any)

A

Old MAOI:
-MAO-A inhibition: less breakdown of 5HT/NA

-MAO-B inhibition: less breakdown of dopamine

Clinical use:
Panic, Social Phobia, Agoraphobia

Side effects:
Overdose risk due to stimulant effect (from increased dopamine)

17
Q

Tranylcypramine

+ clinical use + significant side effects (if any)

A

Old MAOI:
-MAO-A inhibition: less breakdown of 5HT/NA

-MAO-B inhibition: less breakdown of dopamine

Clinical use:
Panic, Social Phobia, Agoraphobia

Side effects:
Overdose risk due to stimulant effect (from increased dopamine)

18
Q

Moclopemide

+ clinical use + significant side effects/interactions (if any)

A

New MAOI:
-MAO-A inhibition: less breakdown of 5HT/NA

Clinical use:
Panic, Social Phobia, Agoraphobia

Side effects

  • interactions with SSRI (hyperthermia, confusion, hypertensive crisis)
  • high absorption of dietary amines –> leads to hypertensive crisis
19
Q

Mirtazepine
+ pharmacodynamics
+ clinical use + significant side effects/interactions (if any)

A

Atypical antidepressant

Pharmacodynamics:
high affinity for H1 receptor
presynaptic alpha2 receptor antagonist

Clinical use:
Depression (second most commonly prescribed after fluox)

Side effects:

  • Sedation, weight gain
  • Contraindicated in those with cardiac problems, blood disorders (e.g. anaemia)
20
Q

Nefazodone
+ pharmacodynamics
+ clinical use + significant side effects/interactions (if any)

A

Atypical antidepressant

Pharmacodynamics:
High affinity for 5HT(2A) receptor

Clinical use:
Depression

Side effects:
Affects slow wave sleep

21
Q

Mianserin
+ pharmacodynamics
+ clinical use + significant side effects/interactions (if any)

A

Atypical antidepressant

Pharmacodynamics:
High affinity for H1 & 5HT(2A) receptor

Clinical use:
Depression

Side effects:

  • Sedation, weight gain
  • Affects slow wave sleep
22
Q

Sodium valproate

Pharmacodynamics
+ clinical use
+ side effects

A

Pharmacodynamics:
Blocks voltage gated Na channels
Increases GABA levels

Clinical use:
Mania, bipolar, epilepsy

Side effects:
COMMON: nausea, abdominal pain, weight gain, thrombocytopenia, thinning hair
UNCOMMON: agitation, ataxia, tremor

23
Q

Lithium

+ clinical use
+ side effects
+ risks

A

Clinical use: (mood stabiliser)
Recurrent depression, Mania, bipolar

Side effects:
COMMON: thirst, polyuria, weight gain, tremor
UNCOMMON: V&D, abdominal pain, ataxia, drowsiness

Risks:

  • thyroid dysfunciton
  • renal impairment
  • toxicity
  • relapse if stopped suddenly
  • requires regular blood tests

CPTP stage 3 (15 decks)

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