CPN Exam Endocrine/Metabolic Flashcards

1
Q

Hypothyroidism

A

Thyroid gland secretes too little thyroid hormone
Congenital/Acquired

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2
Q

Hypothyroid Assessment

A

Impaired growth and development
Constipation
Sleepiness
Hypotonia
Hypothermia
Weight gain

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3
Q

Hypothyroid Management

A

Thyroid Hormone (TH) replacement– Prompt treatment is required for the infant to reduce neurologic impairment
Monitor progress of growth and development which should resolve with adequate treatment
Routine monitoring of serum TH levels

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4
Q

Hyperthyroidism (Grave Disease)

A

Thyroid gland over secretes thyroid hormone

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5
Q

Hyperthyroidism Assessment

A

Irritability and emotional lability
Short attention span
Weight loss despite voracious appetite Accelerated linear growth and bone age Hyperactivity of GI Tract
Hyperactivity
Tremors
Insomnia
Tachycardia
Tachycardia, bounding pulse

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6
Q

Hyperthyroidism Treatment

A

Drug therapy
Propylthiouracil (PTU)
Methimazole (MTZ, Tapazole)
Subtotal thyroidectomy
Ablation with radioiodine

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7
Q

Thyrotoxicosis Thyroid Storm

A

Sudden symptoms such as rapid heart rate, blood pressure and increased body temperature (manifested as fever)– Requires immediate medical attention (give an anti-thyroid drug)

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8
Q

Cushing Syndrome

A

A cluster of clinical abnormalities resulting from excessive levels of adrenocortical hormones.

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9
Q

Cushing Syndrome Etiologies

A

(1.) Adrenocortical tumor (infants and young children)
(2.) Excessive or prolonged steroid therapy (older children)

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10
Q

Cushing Syndrome Assessment

A

Central Obesity
Moon face
Susceptibility to infection/wound healing
Hypertension
Osteoporosis
Hirsutism
Mood disorder

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11
Q

Cushing Syndrome Management

A

Gradual discontinuation of exogenous steroids
Surgical removal of tumor
Steroid replacement therapy

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12
Q

Diabetes Insipidus (DI)

A

Hi and dry” = hi sodium (Na) and dehydration
Posterior pituitary hypofunction resulting in a hyposecretion of antidiuretic hormone (ADH) also called vasopressin

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13
Q

DI Assessment

A

Large volumes of urine and diuresis (i.e. polyuria)
Intense polydipsia (thirst)

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14
Q

DI Management

A

Hydrate
– Oral administration of water
– IV fluids
Drug therapy (oral or nasal)– DDAVP (exogenous vasopressin)

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15
Q

Syndrome of Inappropriate Antidiuretic Hormone (SIADH)

A

syndrome of hyponatremia and hypoosmolality that results from the excessive production or release of antidiuretic hormone (ADH) also called vasopressin which causes diminished water elimination.

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16
Q

SIADH

A

Opposite of DI is “low and too much H20” = low sodium (Na) and over volumized– Low Na is a risk for cerebral edema

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17
Q

SIADH Assessment

A

Decreased urine, fluid retention, weight gain, hyponatremia, muscle weakness, lethargy, confusion, seizures
Serum Laboratory Tests:
-Osmolality is low = means there is ↑ fluid volume and ↓ solute volume
-Blood Urea Nitrogen (BUN) is low = due to total body water dilution

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18
Q

SIADH Management

A

Correct hyponatremia with neurologic monitoring
Drug therapy: vasopressin receptor antagonists; diuretics
Fluid restrictions and fluid monitoring
Neuro checks and seizure precautions

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19
Q

Type I Diabetes

A

Most common endocrine disease in children
Autoimmune disorder causing destruction of the pancreatic beta cells
No insulin is produced so cells cannot utilize glucose

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20
Q

Hyperglycemia

A

Polyuria
Polydypsia
Polyphasia
“Warm and Dry - Sugar High”
Acetone breath

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21
Q

Pre-Diabetes

A

Fasting Glucose: 100-125
Normal <99

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22
Q

Hypoglycemia

A

Glucose <70
Sweaty, Shaky, Tachycardia, behavior changes
“Cold and clammy, need some candy”

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23
Q

HgbA1c

A

<7% for Type I

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24
Q

Type I Diabetes Management

A

Monitor blood glucose frequently
– Before meals and snacks
– Before and mid-way point when starting new physical activities
Carbohydrate, fat, and protein counting
Administration of insulin
Promote regular exercise and a healthy weight

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25
Diabetes and Exercise
↓ blood glucose and ↓ insulin needs – Either ↓ insulin dose or add 1-2 “uncovered snack(s)”
26
Diabetes and Sick Day/Illness
↑ blood glucose and ↑ insulin needs – “Sick day rules” with more frequent blood glucose monitoring and insulin “touch ups
27
Hyperglycemia Management
Give rapid-acting insulin Give fluids without sugar to flush out ketones (This includes IV fluid.)
28
Hypoglycemia Management
Give fast-acting carbohydrate (1/2-cup orange juice or soda) -Avoid complex carbohydrates such as a candy bar – Give glucagon for unconscious child Place on side to prevent aspiration with vomiting (i.e. side effect of glucagon)
29
Insulin
Lispro/Humalog (Rapid Acting) – Onset: 10-15 minutes – Peaks: 30-90 minutes NPH (Intermediate Acting) – Onset: 2-4 hours – Peaks: 8 hours Lantus (Long Acting) – Basal needs; no peaks; not related to meals
30
Type II Diabetes
Insulin resistance (varying degrees) with some insulin deficiency
31
Type II Diabetes Symptoms
Overweight/obesity Sleep apnea – Hypertension Hyperlipidemia – Acanthosis Nigricans (90% of kids with type 2 DM) -Cutaneous thickening and hyperpigmentation
32
Bones in Pediatric Patients
Bone lengthening happens in epiphyseal plates Damage to plates can impact growth Healing is faster in kids - 1 week for every year of age up to 10
33
Most common fracture in peds
Clavicular Greenstick
34
Clavicular Fracture
Occur during vaginal birth due to width of shoulders
35
Greenstick
Occur in long bones due to flexibility of growing bones
36
Spiral
associated with a twisting force; more closely associated with child abuse than other fractures but also seen in sports injuries like skiing
37
Compound
Bone breaks skin
38
Comminuted
Bone breaks into pieces
39
Casts
Plaster casts: less common; less expensive Fiberglass casts: more common, lighter, better air flow, better X-ray visualization; more expensive
40
Fracture Assessment
Assess Circulation: -Color -Pulses -Sensation -Movement -Temperature -Edema -Wiggle toes/fingers without tingling/numbness
41
Cast Management
Elevate extremity 24-72 hours after placement (reduces swelling and tightness) Antihistamines for itching Nothing inside the cast Regularly assess circulation Check for pressure as child grows Cover cast when bathing/in water
42
Compartment Syndrome
Complication of a fracture causing swelling or bleeding occurs within a compartment leading to increased pressure and disruption of blood flow to muscles and nerves – Can lead to tissue death and permanent disability
43
Neurovascular Assessment
Pallor - lack of profusion Pain - most important finding, more intense than expected Pulse - weak or absent Paralysis - inability to wiggle toes or fingers Paresthesia - tingling/Numbness
44
Traction
Designed to decrease muscle spasms and realign and position bone ends
45
Skin Traction
uses adhesive, moleskin, elastic bandage to pull indirectly on the skeleton
46
Skeletal Traction
Uses pins and tongs to pull on skeleton directly
47
Traction Assessment
Assess skin at site of pin insertion Neurovascular assessment of extremity (pulses, warmth, brisk cap refill) Assure that weights hang freely Use pressure reducing surfaces Prevent constipation (fluids, fiber, stool softeners) Manage pain Provide developmental stimulation
48
Spica Cast
Extends from mid-chest to legs Legs are abducted with a bar between them (never lift using bar)
49
Spica Cast Care
Place disposable diaper under edges to prevent cast from getting soiled Elevate head of bed so urine and stool drain downward Reposition frequently to reduce pressure; check for pressure as the child grows
50
Development Dysplasia of Hip
Abnormal development of the hip socket– Head of the femur comes out of the hip socket Present at birth Can affect one or both hips
51
Etiology of DDH
Breech Delivery Fetal position in utero genetic predisposition
52
DDH Assessment
Ortolani/Barlow Sign or Click Shortened limb on the affected side (telescoping) Asymmetrical skin folds in gluteus and thighs from telescoping and dislocation
53
DDH Treatment
Treated with Pavlik harness continuously for 6-12 weeks – Effective in 95% of cases Surgical reduction with hip-spica casting (for those not responsive to Pavlik harness
54
Osteogenesis Imperfecta
Genetic disorder characterized by bones that break easily due to a collagen defect– Classified from less to more severe (e.g. from a few to hundreds of fractures in a lifetime)
55
OI Assessment
Bones fracture easily, sclera is a blue tint, brittle teeth, thin skin, small stature, spinal curvature
56
OI Intervention
No cure exists, maximize bone mass and muscle strength through exercise (e.g. swimming and walking, if able
57
Osteomyelitis
An infection in a bone spreading from the bloodstream, adjacent tissue, or bone injury
58
Osteomyelitis organism
most commonly staphylococcus bacteria commonly found on skin and in nose of even healthy individuals
59
Osteomyelitis Assessment
More common in long bones in kids* Fever, pain, swelling, warmth, redness in affected region
60
Osteomyelitis Management
4 to 6-week course of antibiotics May require surgical removal of infected or necrotic tissue
61
Scoliosis
A lateral curvature of the spine that may occur in the thoracic, lumbar, or thoracolumbar spinal segment
62
Scoliosis Complications
Impaired growth and development – Impaired mobility – Debilitating pain – Respiratory compromise
63
Non-Structural Scoliosis
Unequal leg lengths Abnormal posture C-shaped curvature of spine – Curve disappears when child bends at the waist to touch the toes (Adams-Bend test)
64
Scoliosis Management
Shoe lifts (if unequal leg lengths the cause) – Postural exercises (if poor posture is the cause)
65
Structural Scoliosis
An S-shaped curvature of the spine – Asymmetry of hips, ribs, shoulders, scapula – Curve does NOT disappear when the child bends at the waist to touch the toes (Adams-Bend test)
66
Structural Scoliosis Diagnosis
Diagnostic tests – X-rays of the spine (definitive diagnosis)
67
Structural Scoliosis Management
For mild to moderate curvatures < 40 degreeso Prolonged bracing Tight t-shirt underneath Keep skin beneath the brace clean and dry Wear the brace as ordered (16-23 hours per day) Provide psychological support Traction Electrical stimulation