CPC Neoplasia

Question 1

most common cause of female cancer mortality worldwide

Answer 1

cervical cancer

Question 2

what does cervical disease start as

Answer 2

benign noninvasive or squamous intraepithelial lesion

10-15% progress to moderate or severe dysplasia

Question 3

mechanism of high risk HPV

Answer 3

protein E6 interacts with p53 in host cell–>promotes degradation via ubiquitin dependent pathway

protein E7 complexes with Rb–>inactivating it

Question 4

Rb and p53 are

Answer 4

tumor suppressors

Question 5

procedures that target the infected area..

Answer 5

do NOT get rid of HPV

Question 6

procedures for HPV

Answer 6

leep- cuts of infected site
laser- burns off infected site
cryosurgery- freezes off infected site
general surgery- hysterectomy, vulvectomy
natural products- stress, immune system boosters

Question 7

cervical cancer screening guidelines

Answer 7

approx 3 years after onset of vaginal intercourse, but no later than age 21

Question 8

ASCUS

Answer 8

atypical cells of unclear significance

repeat Pap vs. test for HPV DNA

Question 9

LSIL

Answer 9

low grade squamous intra-epithelial lesion

colposcopy with biopsy

Question 10

HSIL

Answer 10

high grade squamous intra-epithelial lesion

colposcopy with biopsy and treat

Question 11

CIN 1

Answer 11

mild dysplasia–usually spontaneously regresses