Cough Suppressants, Decongestants, and Mucolytics

Question 1

Drugs used for a nonproductive cough

Answer 1

Antitussives:
A. Systemic agents:
1. Dextromethorphan 
2. Diphenhydramine
3. Codeine
4. Benzonatate
B. Topical agents:
1. Camphor
2. Menthol

Question 2

Dextromethorphan

1. MOA
2. Metab
3. AEs
4. Contras

Answer 2

1. Suppresses cough by direct action on cough center in medulla of brain
2. CYP (2D6)
3. Dizziness, drowsiness, N/V, diarrhea, irritability, tachycardia, insomnia
4. those on antidepressant MAO and serotonin uptake inhibitors, resp insufficiency or hepatic disease, hypersensitivy