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RUSVM BacT Exam 1 > Corynebacterium > Flashcards

Corynebacterium Flashcards

1
Q

Corynebacterium contains what in the cell wall?

A

Mycolic Acid

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2
Q

Where is Corynebacterium found?

A

Commensals (mucous, skin), soil and other environmental sources

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3
Q

What type of pathogens are Corynebacterium?

A

Opportunistic

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4
Q

What type of infections are assoc. with Corynebacterium?

A

Pyogenic infections

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5
Q

C. Diphtheriae is carried in what?

A

A bacteriophage

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6
Q

C. Diphtheriae causes disease in what age group?

A

Children - whooping cough

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7
Q

What other corynebacterium spp. contain diphtheria toxin?

A

C. Psuedotuberculosis and C. Ulcerans

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8
Q

C. Pseudotuberculosis causes what lesion in sheep and goats?

A

Caseous lymphadenitis AND chronic pyogranulomatous infections of lymph nodes

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9
Q

C. pseudotuberculosis is what kind of pathogen?

A

Facultative intracellular pathogen (survives inside macrophage to produce Chronic Granulomatous Disease)

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10
Q

Local lymphadenitis assoc. with C. pseudotuberculosis is caused by:

A

Penetration of skin, minor wounds, and bites

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11
Q

Virulence factors of C. Pseudotuberculosis are

A

Exotocin, phospholipase D - enhances the spread of bacteria by damaging endothelial cells and increasing vascular permeability

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12
Q

Damage to endothelial cells and increasing vascular permeability is caused by what virulence factor? (Of C. pseudotuberculosis)

A

Exotoxin phospholipase-D

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13
Q

Corynebacterium pseudotuberculosis severity __________ with age

A

Increases

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14
Q

C. pseudotuberculosis: Caseous lymphadenitis characteristics

A

Abscess formation in major lymph nodes (external form - common in goats)

Abscess are formed within internal organs and lymph nodes (internal form - common in sheep)

Economic losses from death

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15
Q

C. pseudotuberculosis: caseous lymphadenitis features?

A

Lamellated “onion skin” appearance

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16
Q

What type of necrosis is assoc. with caseous lymphadenitis?

A

Caseous necrosis - abscesses rapidly encapsulated by fibrous CT

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17
Q

Cells that are no longer recognizable; tissue architecture that is lost is a characteristic of _____________ necrosis

18
Q

Tissue architecture is preserves; identify of the necrotic cells is recognizable. - what type of necrosis is this?

A

Coagulative

19
Q

What are the signs assoc. with C. pseudotuberculosis

A

Abscess and chronic weight loss

20
Q

What test is used for the diagnosis of C. pseudotuberculosis

A

Synergistic hemolysin inhibition test (SHI) - detect Ab’s to phospholipase D exotoxin

21
Q

What are positive titers indicative of?

A

Past resolved infection, recent exposure, recent vaccination, or active lesions

22
Q

What test can you use for CONFIRMATION of C. Pseudotuberculosis?

A

Paired Titers can be used for confirmation

23
Q

Why might it be difficult to detect in young animals?

A

Due to the presence of maternal antibodies

24
Q

What can you use for treatment and control?

A

Penicillin, Rifampin, Tulathromycin

25
Q

Are vaccines available?

A

For sheep and goats, YES

26
Q

What is the disease caused in horses?

A

Pigeon fever in horses - Colorado Strangles - “dry-land distemper”

27
Q

Where are the lesions typically found?

A

On the lower extremities

28
Q

What is the disease name in cattle?

A

Bovine ulcerative lymphagitis

29
Q

What are the vectors for C. pseudotuberculosis ?

A

Arthropod Vectors : stable flies, horn flies, and house flies; OR contaminated fomites/soil

30
Q

How does C. Pseudotuberculosis enter the body?

A

Through skin abrasions

31
Q

C. Renale groups is also known as: _______________

A

Contagious Bovine Pyelonephritis

32
Q

Which 3 bacteria do C. renale contain?

A

C. renale
C. cystiditis
C. pilosum

33
Q

Which age group does C. renale target?

A

Adult cows

34
Q

Where does C. renale group bacteria reside?

A

Lower Urogenital Tract of cattle and sheep

35
Q

What are some AM signs assoc. with C. Renale

A 
Temp increase
Weight loss
painful urination
Colic
Ammonia odor
Decreased milk production
Decreased rumen contractions
36
Q

What are the PM signs assoc. with C. renale?

A
  • Multifocal abscesses in renal cortex, medullary, pelvis

- Uremia

37
Q

C. Kutscheri is also known as

A

Murine pseudotuberculosis

38
Q

What tissue does C. kutscheri target and what does it cause?

A

The Lungs, and suppurative penumonia

39
Q

What is the host for C. bovis?

40
Q

What clinical signs are associated with C. bovis?

A

Dermatitis, hyperkeratosis

41
Q

What is the disease associated with C. renale group?

A

Contagious Bovine Pyelonephritis

42
Q

What is the “bio type” that causes Pigeon Fever in Horses infected with C. pseudotuberculosis?

A

Nitrate Reducing Biotype

RUSVM BacT Exam 1 (15 decks)

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