Corynebacterium Flashcards
Corynebacterium contains what in the cell wall?
Mycolic Acid
Where is Corynebacterium found?
Commensals (mucous, skin), soil and other environmental sources
What type of pathogens are Corynebacterium?
Opportunistic
What type of infections are assoc. with Corynebacterium?
Pyogenic infections
C. Diphtheriae is carried in what?
A bacteriophage
C. Diphtheriae causes disease in what age group?
Children - whooping cough
What other corynebacterium spp. contain diphtheria toxin?
C. Psuedotuberculosis and C. Ulcerans
C. Pseudotuberculosis causes what lesion in sheep and goats?
Caseous lymphadenitis AND chronic pyogranulomatous infections of lymph nodes
C. pseudotuberculosis is what kind of pathogen?
Facultative intracellular pathogen (survives inside macrophage to produce Chronic Granulomatous Disease)
Local lymphadenitis assoc. with C. pseudotuberculosis is caused by:
Penetration of skin, minor wounds, and bites
Virulence factors of C. Pseudotuberculosis are
Exotocin, phospholipase D - enhances the spread of bacteria by damaging endothelial cells and increasing vascular permeability
Damage to endothelial cells and increasing vascular permeability is caused by what virulence factor? (Of C. pseudotuberculosis)
Exotoxin phospholipase-D
Corynebacterium pseudotuberculosis severity __________ with age
Increases
C. pseudotuberculosis: Caseous lymphadenitis characteristics
Abscess formation in major lymph nodes (external form - common in goats)
Abscess are formed within internal organs and lymph nodes (internal form - common in sheep)
Economic losses from death
C. pseudotuberculosis: caseous lymphadenitis features?
Lamellated “onion skin” appearance
What type of necrosis is assoc. with caseous lymphadenitis?
Caseous necrosis - abscesses rapidly encapsulated by fibrous CT