Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

RUSVM BacT Exam 1 > Antimicrobials > Flashcards

Antimicrobials Flashcards

1
Q

Distruption of cell wall synthesis and stimulation of autolysins (degrade peptidoglycans) are the mechanisms of action of WHAT antimicrobials?

A

Beta-Lactams

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Inhibition of protein synthesis (bind to 30s) is an action of which antimicrobial(s)?

A

Tetracyclines and Aminoglycosides

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Inhibition of protein synthesis (binding to 50s subunit) is a function of which antimicrobial(s)?

A

Macrolides

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

B-Lactams, Aminoglycosides, and Fluoroquinolones are considered: Bactericidal OR Bacteristatic?

A

Bactericidal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Which antimicrobials are Bacteristatic?

A

Tetracyclines and Macrolides

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Which antimicrobial is associated with Type 1-Hypersensitivity (anaphylactic reaction)?

A

Beta-Lactams

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Which antimicrobial is typically used in ruminants and swine?

A

Tetracyclines

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Tetracycline and Macrolides are considered: Bactericidal or Bacteristatic?

A

Bacteristatic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Which antimicrobial has Synergism with B-lactams but Physically incompatible with B-lactams?

A

Aminoglycosides

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Inhibition of DNA gyrase and DNA replication is an action of which antimicrobial?

A

Fluoroquinoloes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Fluoroquinolones have synergism with ______________ and ____________

A

beta-lactate and aminoglycosides

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Fluoroquinolones are NOT effective against ___________

A

Anaerobes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Intracellular accumulation in phagocytes is a characteristic of which antimicrobial(s)?

A

Macrolides

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Which antimicrobial(s) are excreted though bile, feces, and urine?

A

Sulfa or Potentiated Sulfa Drugs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Sulfa or Potentiated Sulfa drugs are synergistic with ___________________

A

Diaminopyrimidines (trimethoprim, and pyrimethamine)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Penicillins, cephalosporins, sublactams, carbapenems (Imipenem), and monobactams are members of ___________

A

Beta-lactam antimicrobials

17
Q

Because Beta-lactams rely on time-dependent killing, how does this correlate to dosing?

A

Need FREQUENT dosing

18
Q

Antagonism of B-lactams is achieved using _____________ and ___________ antimicrobials

A

Tetracycline and Chloramphenicol

19
Q

Tooth discoloration, cardiovascular effect, nephrotoxicity, and alteration of intestinal flora and enterocolitis is associated with which antimicrobial?

A

Tetracyclines

20
Q

IV administration of Doxycycline may result in what (in horses)?

A

Cardiovascular collapse

21
Q

Ototoxicity, Cranial never VII toxicity, vestibular or cochlear damage is associated with which antimicrobial and which spp. more susceptible?

A

Aminoglycosides and cats are more susceptible

22
Q

Which antimicrobial has synergism with Beta-lactate and aminoglycosides?

A

Fluoroquinolones

23
Q

Canine toxic shock syndrome and articular cartilage degeneration in juvenile dogs is associated to which antimicrobials?

A

Fluoroquinolones

24
Q

Fluoroquinolones cause what degeneration in CATS?

A

Retinal Degeneration

25
Q

Inhibition of the nucleic acid synthesis pathway is associated with____________?

A

Sulfa or Potentiated Sulfa drugs

26
Q

Which drugs have a broad spectrum of activity?

A

B-lactams, Tetracyclines, Potentiation Sulfa drugs

27
Q

Which antimicrobial is a good agent against Bacteria AND Protozoa?

A

Sulf or Potentiated Sulfa Drugs

28
Q

Which antimicrobials are excreted through the kidneys (renal excretion)

A

Aminoglycosides and B-lactams

29
Q

What are the resistance mechanisms for B-lactams?

A

B-Lactamase (cleaves B-lactam ring)
Extended spectrum B-lactamase
Alteration in penicillin binding proteins

30
Q

T/F: Penicillin and aminoglycosides can be mixed in the same syringe?

A

FALSE

31
Q

What is the synergistic action of Beta-lactams and Aminoglycosides?

A

Facilitate entry into bacterial cells

32
Q

Inhibition of B-lactamase is achieved using synergistic action of?

A

B-lactams + Clavulanic acid/ sulbactam/ tazobactam

33
Q

Tetracycline members all of the suffix: -__________

A

-cycline

34
Q

Time dependent antimicrobials are (2):

A

Tetracyclines and B-lactams

35
Q

Which antimicrobial can cross the placental barrier, secreted in milk, and has anti-inflammatory/neuroprotective/immunomodulant effects?

A

Tetracycline

RUSVM BacT Exam 1 (15 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions