Corticosteroids Flashcards
what are corticosteroids
–steroids
–are a group of chemicals secreted by the adrenal cortex and are referred to as adrenal cortical hormones
–they are controller… not a rescue agent
Mode of Action of Corticosteroids
–steroids work by reducing inflammation, swelling, and mucus production in the airways. As a result, the airways are less inflamed and less likely to react to triggers
Indications for Use of Inhaled Corticosteroids
–maintenance, control therapy of chronic persistent asthma
-helps prevent the symptoms of asthma
-COPD
-Intranasal aerosol agent: seasonal and perennial allergic and nonallergic rhinitis
Aerosol Steroids: Asthma
–Early use in asthma:
reduces morbidity and airway hyperresponsiveness
spacer is recommended
–Acute Severe Asthma:
not beneficial, for controlling rather than relieving can help improve lung function
–Inhaled Corticosteroids
low dose preferred for decreased side effects
Aerosol Steroids: COPD
–relieves symptoms and exacerbations
–little or no effect on FEV1
Inhaled Corticosteroids: Beclomethasone Dipropionate
–Trade Name: Qvar
–Method of Admin: is a breath-actuated MDI, primeless canister, does not need to be shaken due to having a primeless canister
Inhaled Corticosteroids: Flunisolide
–Trade Name: AeroSpan
–Method of Admin: MDi manufactured with a spacer attached
Inhaled Corticosteroids: Fluticasone Propionate
–Trade Name and Admin: Flovent HFA MDI
Flovent Diskus DPI
ArmonAir Respiclick DPI: spacer should not be used
Inhaled Corticosteroids: Fluticasone Furoate
–Trade Name: Arnuity Ellipta
–Admin: DPI has better affinity for the glucocorticoid receptor this providing a longer duration action
–Given once daily
Inhaled Corticosteroids: Budesonide
–Trade Name and Admin: Pulmicort Flexhaler DPI
Pulmicort respules SVN: is the inhaled corticosteroid available as an SVN. Can be mixed with other liquid medication
Inhaled Corticosteroids: Mometasone furoate
–Trade Name and Admin: Asmanex Twisthaler, DPI,given once daily
Asmanex HFA, MDI, Twice daily over age 12
Inhaled Corticosteroids: Ciclesonide
–Trade Name: Alvesco MDI
–for ages 12 and older
–decreases the incidence of oral thrush
Comination Corticosteroids: Fluticasone Propionate / Salmeterol
–Trade Name and admin: Advair Diskus, DPI
Advair HFA, MDI
AirDuo Respiclick, DPI, is not used with a spacer/holder chamber
Combination Corticosteroids: Mometasone Furoate / Formterol
–Trade Name and Admin: Dulera, MDI
–increase lung function as a combination drug
–steroid and bronchodilator
Combination Corticosteroids: Budesonide / Formoterol
–Trade Name and Admin: Symbicort, MDI, increase beta-adrenergic receptor transcription
Combination Corticosteroids: Fluticasone furoate / vilanterol
–Trade Name and Admin: BreoEllipta, DPI, contains 2 double-foil blisters of powder formulation
Triple Therapy Coricosteroid: Fluticasone furoate / umeclidinium / vilanterol
–Trade name and Admin: Trelegy Ellipta, DPI
–Treats: COPD
–not allow to change the dose of each drug in it
Steroid hazards and side effects
–systemic administration
–suppression of the Hypothalamic-Pituitary- Adrenal (HPA)
–immunosuppression
–peptic ulcer
–hypertension
–increase WBC
–slowing growth in children
Systemic side effects
–aerosol admin
–HPA suppression
–Loss of bone density
–growth restriction in children
Inhaled Corticosteroid Assess.
–instruct patient in correct use of delivery
–respiratory assess
–subjective response
–use a peak flow meter
–exacerbations
–missed work/school
–ER vists
–assess for side effects
A side effect of corticosteroid use is inhibition of?
–HPA axis
the product combining an inhaled steroid and a bronchodilator is?
–dulera
