Anticholinergic Bronchodilators Flashcards
What is it use for
–it is an antimuscarinic agent
–maintenance of
Atropine Sulfate
–use a bronchodilator, nor aerosolized
–given by IV
–easily absorbed in the bloodstream
–Many Side Effects:
-inhabits mucus production and reduces mucociliary clearance
-blurred vision
-restlessness, irritability
-increases HR
Inhaled Anticholinergic
Bronchodilator: Ipratropium Bromide
–Method of Admin:
-MDI: 17mcg/puff, 2 puffs qid
-SVN: 0.02% solution (0.2mg/ml) TID or Qid
-Nasal spray: 0.03%, 21mcg/spray, 2 sprays per nostril BID or TID
0.06%, 42 mcg/spray, TID or QID
–Onset: 15-30min
–Peak: 1-2 hrs
–Duration: 6hrs
–Treats: maintenance of airway obstruction in COPD
-Nasal spray: common cold, retinopathies and rhinorrhea
–Trade Name: Atrovent
Inhaled Anticholinergic
Bronchodilator: Ipratropium and Albuterol
–Method of Admin:
-DuoNeb SVN: 0.5 mg ipratropium and 2.5 mg albuterol
-trade Name: Combivent Respimat (soft mist inhalar): 20 mcg ipratropium and 100 mcg albuterol/puff, qid
–Treats: More effective when combined in stable COPD
–Onset: 15 min
–Peak: 1-2hrs
–Duration: 6 hrs
Inhaled Anticholinergic
Bronchodilator:Glycopyrrolate Bromide
–Method of Admin: Seebri Neohalar DPI 15.6 mcg/inhalation BID
Lohala Magnir a liquid form utilizing a vibrating mesh nebulizer VMN 25mcg/1 mL BID
–Onset: 15-30min
–Peak: 1-2hrs
–Duration: 12hrs
–Treats: COPD
-administered parenterally to reverse neuromuscular blockade and nebulized for bronchodilation
Inhaled Anticholinergic
Bronchodilator:Glycopyrrolate bromide in Combination
–Glycopyrrolate with indacaterol (Ubitron Neohalar): DPI 15.6 mcg/inhalation and 27.5 mcg/inhalation indacaterol BID
–Glycopyrrolate with Formoterol (Bevespir Aerosphere): MDI 9mcg/inhalation and 4.8 mcg/inhalation indacaterol BID
–Treats: COPD
–Onset: 5-15min
–Peak: 30min-1hr
–Duration: 12hrs
Inhaled Anticholinergic
Bronchodilator:Glycopyrrolate
–Method od Admin: 0.03mg/kg TID, 1hr before meals or 2hrs after meal
-IV: to reverse neuromuscular blockade
–Treats: excessive secretion
–Trade Name: Robinul
Inhaled Anticholinergic
Bronchodilator:Aclidinium Bromide
–Method of Admin: DPI 400mcg/inhalation, 1 inhalation BID
–Onset: 10-20 min
–Peak: 30min- 1hr
–Duration: 12hrs
–Treats: maintenance of COPD
–Trade Name: Tudorza Pressair
Inhaled Anticholinergic
Bronchodilator:Aclidinium Bromide and Formoterol
–A combination drug
–Method of Admin: DPI 400mcg/12mcg inhale BID
–Onset: 10-20 min
–Peak: 30min/1hr
–Duration: 12hrs
Once-Daily
Anticholinergic
Bronchodilators: Tiotrpium Bromide
–Method of Admin: 18 mcg/inhale
-SMI COPD: 2.5mcg/inhale QP
-SMI Asthma: 1,2mcg/inhale QP
–Treat: reduces COPD exacerbation
-improves quality of life
-slow the decline in patient’s FEV
–Onset: 30min
–Peak:1/3hrs
–Duration: 24hrs
–Trade Name: Spiriva
Once-Daily
Anticholinergic
Bronchodilators: Tiotropium bromide and olodateroal
–Mode of Action: anticholinergic and long-acting beta 2 drug
–Method of Admin: Respimate 2.5 mcg tiotropium and 2.5mcg olodateroal, 2 inhalation once daily
–Onset: 15min
–Peak: 1/2hrs
–Duration: 24hrs
–Trade Name: Stiolto
Once Daily Anticholinergic
Bronchodilators Combination: Umeclidinium bromide and vilanterol
–Mode of Action: anticholinergic and long-acting Beta 2
–Method of Admin: DPI 62.5 mcg umeclidinium and 25mcg vilanterol/puff, QD
–Onset: 5/15min
–Peak: 1/3hr
–Duration: 24hrs
Where do they derive from
–Atropine
What is their structure
–Quaternary form
