Anticholinergic Bronchodilators Flashcards
What is it use for
–it is an antimuscarinic agent
–maintenance of
Atropine Sulfate
–use a bronchodilator, nor aerosolized
–given by IV
–easily absorbed in the bloodstream
–Many Side Effects:
-inhabits mucus production and reduces mucociliary clearance
-blurred vision
-restlessness, irritability
-increases HR
Inhaled Anticholinergic
Bronchodilator: Ipratropium Bromide
–Method of Admin:
-MDI: 17mcg/puff, 2 puffs qid
-SVN: 0.02% solution (0.2mg/ml) TID or Qid
-Nasal spray: 0.03%, 21mcg/spray, 2 sprays per nostril BID or TID
0.06%, 42 mcg/spray, TID or QID
–Onset: 15-30min
–Peak: 1-2 hrs
–Duration: 6hrs
–Treats: maintenance of airway obstruction in COPD
-Nasal spray: common cold, retinopathies and rhinorrhea
–Trade Name: Atrovent
Inhaled Anticholinergic
Bronchodilator: Ipratropium and Albuterol
–Method of Admin:
-DuoNeb SVN: 0.5 mg ipratropium and 2.5 mg albuterol
-trade Name: Combivent Respimat (soft mist inhalar): 20 mcg ipratropium and 100 mcg albuterol/puff, qid
–Treats: More effective when combined in stable COPD
–Onset: 15 min
–Peak: 1-2hrs
–Duration: 6 hrs
Inhaled Anticholinergic
Bronchodilator:Glycopyrrolate Bromide
–Method of Admin: Seebri Neohalar DPI 15.6 mcg/inhalation BID
Lohala Magnir a liquid form utilizing a vibrating mesh nebulizer VMN 25mcg/1 mL BID
–Onset: 15-30min
–Peak: 1-2hrs
–Duration: 12hrs
–Treats: COPD
-administered parenterally to reverse neuromuscular blockade and nebulized for bronchodilation
Inhaled Anticholinergic
Bronchodilator:Glycopyrrolate bromide in Combination
–Glycopyrrolate with indacaterol (Ubitron Neohalar): DPI 15.6 mcg/inhalation and 27.5 mcg/inhalation indacaterol BID
–Glycopyrrolate with Formoterol (Bevespir Aerosphere): MDI 9mcg/inhalation and 4.8 mcg/inhalation indacaterol BID
–Treats: COPD
–Onset: 5-15min
–Peak: 30min-1hr
–Duration: 12hrs
Inhaled Anticholinergic
Bronchodilator:Glycopyrrolate
–Method od Admin: 0.03mg/kg TID, 1hr before meals or 2hrs after meal
-IV: to reverse neuromuscular blockade
–Treats: excessive secretion
–Trade Name: Robinul
Inhaled Anticholinergic
Bronchodilator:Aclidinium Bromide
–Method of Admin: DPI 400mcg/inhalation, 1 inhalation BID
–Onset: 10-20 min
–Peak: 30min- 1hr
–Duration: 12hrs
–Treats: maintenance of COPD
–Trade Name: Tudorza Pressair
Inhaled Anticholinergic
Bronchodilator:Aclidinium Bromide and Formoterol
–A combination drug
–Method of Admin: DPI 400mcg/12mcg inhale BID
–Onset: 10-20 min
–Peak: 30min/1hr
–Duration: 12hrs
Once-Daily
Anticholinergic
Bronchodilators: Tiotrpium Bromide
–Method of Admin: 18 mcg/inhale
-SMI COPD: 2.5mcg/inhale QP
-SMI Asthma: 1,2mcg/inhale QP
–Treat: reduces COPD exacerbation
-improves quality of life
-slow the decline in patient’s FEV
–Onset: 30min
–Peak:1/3hrs
–Duration: 24hrs
–Trade Name: Spiriva
Once-Daily
Anticholinergic
Bronchodilators: Tiotropium bromide and olodateroal
–Mode of Action: anticholinergic and long-acting beta 2 drug
–Method of Admin: Respimate 2.5 mcg tiotropium and 2.5mcg olodateroal, 2 inhalation once daily
–Onset: 15min
–Peak: 1/2hrs
–Duration: 24hrs
–Trade Name: Stiolto
Once Daily Anticholinergic
Bronchodilators Combination: Umeclidinium bromide and vilanterol
–Mode of Action: anticholinergic and long-acting Beta 2
–Method of Admin: DPI 62.5 mcg umeclidinium and 25mcg vilanterol/puff, QD
–Onset: 5/15min
–Peak: 1/3hr
–Duration: 24hrs
Where do they derive from
–Atropine
What is their structure
–Quaternary form
The most common side effect seen with Ipratropium Bromide is
–Dry mouth
Is an anticholinergic bronchodilator given mainly to increase a patient’s HR
–Atropine
Combivent is a combination drug including which two
–Albuterol and ipratropium bromide
