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Farmacologia > Corticosteroides > Flashcards

Corticosteroides Flashcards

1
Q

Clasificacion

A

Mineralocorticoides
Sexocorticoides
Glucocorticoides

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2
Q

Mineralocorticoides

A

Aldosterona
Corticosterona
Desoxicorticosterona DOCA

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3
Q

Sexocorticoides

A

Testosterona
Androsterona
Dehidroepiandrosterona

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4
Q

Glucocorticoides

A

Cortisol

Hidrocortisona

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5
Q

Clasificacion glucocorticoides

A

Naturales (accion breve)

Biosinteticos:
1 Gen (accion intermedia)
2 gen (accion prolongada)
3 gen (accion prolongada)
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6
Q

1a generacion

A

Prednisona

Metilprednisolona

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7
Q

Accion breve

A

Naturales

2 hrs

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8
Q

Naturales

A

Cortisol o hidrocortisona

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9
Q

2a generacion

A

Dexametasona
Betametasona
Beclometasona
Fluocinolona

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10
Q

Accion prolongada

A

2a gen
3a gen
1-3 sem

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11
Q

Accion intermedia

A

1a gen

4 hrs

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12
Q

3a gen

A

Budesonida
Deflazacort
Fluticasona

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13
Q

Absorcion

A

Todas vias

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14
Q

Distribucion

A

Proteinas

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15
Q

Metabolismo

A

Hidroxilacion
Reduccion
Conjugacion

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16
Q

Excrecion

17
Q

Farmacodinamia

A 
Union a receptor glucocorticoideo GR
Inhibe:
ac araquidonico
eicosanoides
Prostaglandinas
Tromboxanos
Leucotrienos
Citocinas
TNFa
Interferon
Colagenasa
Fibroblastos
Fibrina
Colageno
Oxido nitrico
Histamina
18
Q

Acciones

A 
Vasoconstriccion
Reducen permeabilidad
Estabilizan lisosomas (proteccion citotoxica)
Catabolismo proteico
Metabolismo carbs: Gluconeogenesis y glucogenesis
Metabolismo lipidos- cushing
Reabsorcion h2o y Na, excrecion K, H
Inhibe histamina
Antiinf: bloquea cinina y COX 2
19
Q

Indicaciones

A 
Enf. Colagena
Alergicas
Respiratorias
Oculares
Renales
Cardiacas
Gastrointestinales
SNC
Hematopoyesis
Diversas
20
Q

Indicaciones colgena

A

Artritis
Lupus
Miositis
Poliarteitis

21
Q

Indicaciones enf. Alergicas

A 
Fiebre heno
Enf. Suero
Dermatitis
Edema angioneurotico
Picaduras, urticaria, eczema
22
Q

Indicaciones cardiacas

A

Carditis reumatoca

23
Q

Indicaciones renales

A

Sx nefrotico

24
Q

Indicaciones gastrointestinal

A

Colitis, crohn, celiaca, esprue

25
Q

Indicaciones SNC

A

Edema cerebral

26
Q

Indicaciones hepaticas

A

Necrosis
Hepatitis
Cirrosis

27
Q

Indicaiones hematopoyeticas

A 
Anemia
Leucemia
Linfoma
Mieloma
Sarcoidosis
Trombocitopenia
28
Q

Indicaciones diversas

A

Shock
Transplante
Insuf suprarrenal
Addison

29
Q

Tx Addison

A

Prednisona

30
Q

Toxicidad

A 
Cushing iatrogenico
Insuf renal
Hiperglucemia
Hipertrogliceridemia
Hiperuricemia
Hipopotasemia
Reten sodio y edema
Ac peptica
infecciones
Cataratas
Osteoporosis
Hipercoagulabilidad 
Hirsutismon acne amenorrea
31
Q

Contarindicaciones

A 
Embarazo
Ulcera
Osteoporosis
Diabetes
Insuf cardiaca
Insuf renal
Infeccion
Tromboembolismo
Queratitis herpetica
Glaucoma
32
Q

Metabolismo de lipidos causa

Farmacologia (7 decks)

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