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pharmacology > Corticoids > Flashcards

Corticoids Flashcards

1
Q

Where are corticoids synthetised?

A

They are steroid hormones synthetised in the Adrenal cortex

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2
Q

Glucocorticoids role

A 
ANTIINFLAMATORIES
IMMUNOSUPRESSORS 
INHIBITION OF LYMPHOID TISSUE
Gluconeogenesis
Lipolysis
Proteolysis
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3
Q

Glucocorticoids

A

Cortisol (Natural adrenal hormone)
Prednisone
Methylprednisone
Dexamethasone

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4
Q

Mechanism of action of gucocorticoids

A

Phospholipase A2 inhibition

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5
Q

Indications of Glucocorticoids

A
  1. Endocrine disease
    Addison’s disease (Adrenal insufficiency, need for steroids)
2. Antiinflamatory
Rheumatic diseases
Bronchial asthma
Digestive inflamatory diseases
Ocular inflamatory diseases
Skin diseases
  1. Allergic diseases
  2. Autoimmune diseases
  3. Organ transplant
  4. Leukemia, Lymphomas
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6
Q

Glucocorticoids ADRs

A
  1. Athrophy of the Adrenal Cortex
  2. Hyperglycemia/lipidemia
  3. Iatrogenic cushing
  4. Muscle athrophy
  5. Loss of bone mass
  6. Digestive disorders
  7. Hormonal changes
  8. Eye disorders
  9. Mental disorders
  10. Mineralocorticoid effects
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pharmacology (8 decks)

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