Coronaviruses

Question 1

coronaviruses

Answer 1

enveloped(SEM), ss + RNA, very large genome, looks like RNA, no polymerase, capsid

Question 2

clinical presentation of coronavirus

Answer 2

common cold (upper respiratory tract infection): sore throat, runny nose, nasal congestion, sneezing coughing muscle aches, fatigue, headache

Question 3

pathogenesis of coronavirus

Answer 3

infects epithelial cells (vacuolated, damage cilia, syncytia) of upper respiratory tract.

Question 4

epidemiology

Answer 4

10-15% upper respriatory infections, glycoprotein “corona” helps survive gastrointestinal tract and transmit via fecal route, aerosol, hand to hand. late winter early spring

Question 5

SARS associated coronavirus

Answer 5

Severe acute respiratory syndrome. respiratory droplets, high fever, pneumonia. Lytic-> diffuse alveolar damage.

Question 6

clinical presentation of SARS

Answer 6

high fever, headache, discomfort, body aches, diarrhea (maybe), dry cough, pneumonia