coronary atherosclerosis & MI

Question 1

wat is the response to injury model for ASCVD?

Answer 1

1. endothelial injury
2. monocytes attach to endothelial cell
3. growth factors released
4. platelets may participate
5. complex lesions evolve over years

Question 2

what is the Intimal collection of MACROPHAGES AND LIPID LADEN SMC’s?

Answer 2

fatty streak

Question 3

what is the advanced lesion?

Answer 3

fibrous plaque

Question 4

what is the MOST COMMON CAUSE OF DEATH IN DIABETIC PATIENTS

Answer 4

atherosclerosis

Question 5

what is unstable angina

Answer 5

new onset, subjectively worse discomfort, onset with less activity, angina at rest

Question 6

typically lasts LESS THAN 30 MINS, onset gradual, worsened by work & lying down

Answer 6

angina

Question 7

stress testing is used to dx

Answer 7

atypical chest discomfort

Question 8

when is stress testing not indicated?

Answer 8

asympt men or women

Question 9

ST depression >2 on stress test is a certain dx of?

Answer 9

Myocardial ischemia

Question 10

do beta blockers have any effect on O2 supply?

Answer 10

no, just reduce myocardial oxygen demand

Question 11

what is a stable angina pectoris?

Answer 11

same pattern each time

Question 12

stress testing can be used for prognosis of?

Answer 12

stable angina, post-MI, post-revascularization

Question 13

what drugs can be used for pharmacological stress testing?

Answer 13

adenosine, dipyramidole, dobutamine

Question 14

what tx for MI decrease pre-load, coronary dilation, enhance endothelial activity

Answer 14

nitrates

Question 15

what tx for MI decrease HR and contractility

Answer 15

beta blockers

Question 16

what tx for MI prevent spasms, reduction of afterload, some reduce contractility, DECREASE AFTERLOAD

Answer 16

CCB

Question 17

factors affecting supply of myocardium

Answer 17

1. vascular resistance
2. coronary blood flow
3. O2 carrying capacity

Question 18

factors affecting demand of myocardium

Answer 18

1. HR
2. contractility
3. systolic wall tension

Question 19

when stress test is combined with ____, it increases the predictive power

Answer 19

imaging (echo or nuclear)