CORE - Mammo Flashcards
Screening women from 40-49 is classified as ___ by USPSTF
Class C - based on individual factors
MLO imaging plane
40-60 degrees from the axial plane; parallel to the pectoralis major; may exclude superior-medial tissue
“Dashes but not dots”
secretory calcifications (plasma cell mastitis); typically bilateral
Cigar-shaped calcifications
secretory calcifications (plasma cell mastitis); typically bilateral
Large rod-like calcifications
secretory calcifications (plasma cell mastitis); typically bilateral
Popcorn calcifications
fibroadenoma
Eggshell or rim calcifications
oil cyst
“Breast within a breast”
hamartoma
Powdered sugar calcifications
amorphous
Coarse heterogeneous calcifications
irregular, >0.5 mm (but smaller than dystrophic calcifications); may be assoc. with malignancy; biopsy is warranted
Dot-dash calcifications
fine pleomorphic (<0.5 mm)
Most suspicious type of calcifications
fine linear-branching (BR-4c) > fine pleomorphic (BR-4b)
Suspicious calcification distributions
segmental (most suspicious) > linear > grouped
BI-RADS for suspicious calcification types
BR-4, unless other suspicious findings are identified on mammo/US (e.g. an associated mass)
Suspected dermal calcifications
tangential view to prove skin location
Tattoo sign
dermal calcifications; fixed relationship between calcifications across different views
Regional distribution of calcifications
distributed over >2 cm; malignancy less likely
Grouped distribution of calcifications
> 5 small calcifications within <2 cm; suspicious
Bilateral flame shaped subareolar masses (male)
gynecomastia
Shrinking breast
ILC
Fat-fluid level
galactocele
Rapidly-growing fibroadenoma
phyllodes tumor
Mastitis refractory to antibiotics
inflammatory breast cancer
Architectural distortion with calcifications
IDC + DCIS
Architectural distortion without calcifications
ILC
Type of DCIS associated with highest rate of recurrence
micropapillary
Snowstorm appearance on US
extracapsular silicone
Stepladder sign on US
intracapsular rupture
Linguine sign on MRI
intracapsular rupture
Calcifications in lumpectomy bed
must exclude residual or recurrent disease
Biopsied calcifications absent from mammo but not in core specimen
likely milk of calcium calcifications; use polarized light
Nipple enhancement on MRI
normal
Darkening of areola
normal with puberty and parity
Breast tenderness peak during cycle
day 27-30
Most comprehensive breast cancer risk model
Tyrer Cuzick (does not include breast density); Gail model is the worst (does not include genetics)
BRCA type most assoc. with male breast cancer
BRCA2
BRCA type more likely to have triple negative cancer
BRCA1
Surgical scars should get lighter over time
If getting darker or focal nodular, consider local recurrence
Silicone in a lymph node on US - NEXT STEP
MRI to evaluate for implant rupture
Biggest risk factor for implant rupture
age of implant
Invasive lobular carcinoma represents ____ of breast cancer
5-10%
Tumor invasion of dermal lymphatics
inflammatory breast cancer
Prognosis for ER/PR positive cancers
good prognosis (better than negative types)
Most common pathogen causing of mastitis
S. aureus; seen in nursing mothers and diabetics
Mondor disease + treatment
thrombophlebitis of a superficial vein; tender; Tx NSAIDs + warm compresses
BI-RADS 3
<2% chance of malignancy; gets 2 year diagnostic follow-up (6-6-12)
BI-RADS 4
2-95% chance of malignancy; benign path result is ok
BI-RADS 5
> 95% chance of malignancy; CANNOT accept a benign path result
BI-RADS 6
biopsy-proven malignancy
Women with extremely dense breasts have a ____ increased risk of cancer compared with almost entirely fatty breasts
5x
Lesion movement based on location - CC => MLO => ML
“Muffins rise, lead falls.” Medial lesions will move up from CC to lateral. Lateral lesions will move down.
New mass on screening mammogram (any characteristics) - NEXT STEP
ultrasound; cannot call any mass benign on screening mammo alone
Pathologic nipple discharge
unilateral; clear or bloody; often spontaneous
Non-pathologic nipple discharge
bilateral; green, brown, or milky
Most common cause of pathologic nipple discharge
papilloma
Clustered microcysts
due to apocrine metaplasia or fibrocystic changes; BR-3 (if no solid component)
ILC (compared to IDC)
more often multifocal and bilateral
Most common type of lymphoma involving the breast
B-cell lymphoma
Non-mammo finding in Poland syndrome
ipsilateral syndactyly; more common in males; often absence of breast tissue as well
Definition of focus on MRI
focal enhancement <5 mm, round/oval, well-circumscribed; no mass effect, no pre-contrast correlate
Normal enhancement at a lumpectomy site can be seen up to
6-18 months, due to granulation tissue; enhancement should not recur after it subsides
Post-radiation therapy increased breast density and skin thickening should peak at…
6 months; beyond 12 months post-radiation it should be considered recurrence until proven otherwise
Eklund view (mammo)
implant-displaced view
Implant type with a valve
saline
Implant type that is semi-lucent
saline
US-guided core biopsy needle characteristics
14G, spring-loaded
Standard breast biopsy needle advances approximately ___ when fired
2 cm
US-guided cyst aspiration needle characteristics
18G or 20G needle (FNA)
Cyst aspirate should be sent for cytology if…
bloody; may discard clear, green, grey, yellow, or cloudy fluid (benign)
Complex cystic mass biopsy - FNA or core
core needle biopsy
Stereotactic biopsy needle characteristics
11G, vacuum-assisted
Components of the mammographic report
history/indication/risk factors, comparison studies, breast composition, findings, impression/BI-RADS/recommendation
Required annotation for US image
side (left/right), clock face position, distance from nipple, orientation of probe
Indications for breast MRI
high risk screening (>20-25% lifetime risk), extent of disease, axillary mets with unknown primary, diagnostic dilemmas, suspected silicone implant rupture, evaluate for recurrence, evaluate for margins after resection, follow response after neoadjuvant chemo
Triple negative cancers
ER, PR, and her2/neu negative; aggressive, bad prognosis; may show paradoxically benign features
Bilateral axillary lymphadenopathy DDx
collagen vascular disease, lymphoma, leukemia, rheumatoid arthritis, HIV
Multiple intraductal papillomas
tend to occur in younger patients than solitary papillomas; not typically assoc. with nipple discharge; increased risk of breast cancer
Multiple skin masses DDx
neurofibromas (NF1), steatocystoma multiplex
Angiosarcoma MRI characteristics
T2 hyperintense, intense enhancement
Mets to the breast
most frequently from melanoma > RCC; also consider contralateral breast cancer if that is an option on multiple choice
Contraindications to stereotactic needle biopsy
<3 cm breast tissue when compressed, far posterior or subareolar location, inability to be positioned on table, uncontrolled coagulopathy
Complicated cyst
contains low-level echoes or layering debris; can perform aspiration or follow with US (BR-3)
Complex cyst
cystic and solid components; solid component needs to be biopsied (BR-4)
Sclerosing adenosis
benign; diffusely scattered microcalcifications
Tail of Spence
axillary extension of breast tissue
Quadrant most breast cancers arise from
upper-outer (most densely populated with fibroglandular tissue)
Regions of breast with least fibroglandular tissues
lower-inner and retroglandular regions (“danger zones” = areas where cancer hides)
Breast asymmetry
normal, but consider a “shrinking breast” (ILC)
Where do most breast cancers start?
TDLU
Lactiferous sinus
dilated portion of major duct just deep to nipple
Major blood supply to the breast
internal mammary artery (medial)
Major lymphatic drainage of the breast
axillary (97% of drainage)
Level 1 axillary nodes
inferior-lateral to pectoralis minor
Level 2 axillary nodes
deep to pectoralis minor
Level 3 axillary nodes
superior-medial to pectoralis minor
Rotter nodes
between pectoralis major and minor
Sternalis muscle
5% of population, usually unilateral; seen on CC view only
Most common location for ectopic breast tissue
axilla > inframammary fold
Most common location for polythelia
axilla > inframammary fold
Best time in cycle for mammogram and MRI
day 7-14 (follicular phase); lowest BPE for MRI