COPD Flashcards
COPD
Preventable and treatable disease characterized by airflow limitation and abnormal inflammatory response in response to noxious chemicals or gases.
Slow, progressive irreversible damage due to chronic bronchitis and/or emphysema
COPD Fax
3rd leading cause of death in US
14.2 mil have it
COPD Risk factors
Smoking is leading cause
Occupational risk
Alcohol, age, gender
COPD Patho
Site of obstruction is in the smaller conducting pathways.
Destruction of alveolar support
Loss of elastic recoil
Structural narrowing sue to inflammation
COPD lung volume changes
Residual volume and functional residual capacity are increased.
Total lung capacity often increased
Vital capacity is reduced
Reasons for decreased vital capacity
Air trapping
Decreased lung recoil
Incomplete lung clearance
COPD is mediated by CD__ Cells
CD8 T lymphocytes
Asthma is CD4
Definition of chronic bronchitis
Blue bloaters
Defined as persistent cough resulting in sputum production for more than 3 months in each of the past 2 years.
Pathologic findings of chronic bronchitis
Goblet cell hyperplasia
Excess mucous secretion
Fibrosis
Chronic bronchitis patients develop hypoxia and cyanosis earlier than emphysema pt’s. T or F
T
Class S/S of chronic bronchitis
Increasingly productive cough
Dyspnea and progressive exercise intolerance
Frequent pulmonary infxns
Weight gain
Emphysema
Pink puffers
Abnormal enlargement of the airspaces distal to the terminal bronchioles.
Destruction of the alveolar walls ad capillary beds.
Abnormal airspaces called bullae compress normal lung.
Loss of lung elasticity
Emphysema Causes
Smoking
Alpha-1 antitrypsin deficiency
Emphysema presentation
Long hx of progressive dyspnea Non-productive cough Initially able to over-ventilate and maintain normal blood gas levels Patients are usually cachectic Pursed lip breathing is helpful
Centrilobular Emphysema
Most common type
Characterized by focal destruction
Seen predominantly in male smokers
Most severe in upper lobes