control of pain + anxiety Flashcards
what is allodynia
pain from non-painful stimuli
what is hyperalgesia
exaggerated response to noxious stimuli
2 effects of paracetamol
antipyretic
analgesia
risk of paracetamol
liver toxicity in compromised pts
risks of NSIADs
gastric ulceration
bleeding
pts when NSAIDs are contraindicated
elderly previous hypersensitivity pregnancy/breastfeeding history of gastrointestinal bleed/ulcer renal impairment hepatic impairment coagulation defects cardiac impairment asthmatics - increased risk of hypersensitivity
drug prescribed alongside NSAIDs to offer gastrointestinal protection
proton pump inhibitors - ols
drugs developed to have same affects as NSAIDs without side effects
selective COX-2 inhibitors
why do NSAIDs cause side effects
not selective - COX1 also inhibited
side effects of opioids
nausea/vomiting
respiratory depression
example of a weak opioid
codeine or dihydrocodeine
example of a strong opioid
morphine
why may it be important to give systemic analgesia before LA worn off?
reduce risk of sensitisation
where are amino-ester LAs metabolised?
in plasma by pseudocholinesterase
where are amino-amide LAs metabolised?
in liver