Control of Cell Cycle Flashcards
1
Q
What does the phosphate Wee 1 Do?
A
It inactivates the Cdk-cyclin complex by phosphorylating two closely spaced sites above the active site
2
Q
How can you re-activate a cyclin-cdl complex once wee 1 has phosphorylsed it?
A
by the phosphatase Cdc25
3
Q
What does CKI stand for?
A
Cdk inhibitor proteins
4
Q
Give an example of a CKI
A
p27
5
Q
What does APC/C stand for?
A
Anaphase promoting complex/Cyclosome
6
Q
What does cell cycle control depend upon?
A
Cyclins, Cdks and Cdk inhibitor proteins
7
Q
What are the first protein kinases at the site of DNA damage?
A
ATM or ATR
