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Neurobiology > Construction of Neural Circuits > Flashcards

Construction of Neural Circuits Flashcards

1
Q

What do cells exist as after neurogenesis?

A

Neuroblasts

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2
Q

What must a neurite contain to become an axon?

A

Par protien

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3
Q

What mediate travel of an axon?

A

Growth Cone

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4
Q

What is a growth cone?

A

Sheet like expansion called lamellipodium, containing filopodia

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5
Q

Describe filopodia

A

Dynamic cytoskeleton & express distinct receptors allowing for expansion & contraction as they search target

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6
Q

What is actin responsible for?

A

Movement of Lamellipodia/filopodia

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7
Q

What are microtubules responsible for?

A

Axon elongation

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8
Q

What is extracellular matrix?

A

Adhesive network or molecules outside of cells

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9
Q

What does extracellular matrix molecules activate?

A

Integrin receptors that control cell motility

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10
Q

What is CAM involved in?

A

Axon fasciculation

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11
Q

What are cadherins involved in?

A

Transition of a growth cone to a mature synapse

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12
Q

What happens when ephrins/Eph have favorable interaction?

A

Promotes adhesion & synaptogenesis

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13
Q

What happens when ephrins/Eph do not have favorable interaction?

A

Cleaved, preventing adhesion & synaptogenesis

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14
Q

What is chemoattraction?

A

Growth cones are moved

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15
Q

Chemorepulsion

A

Growth cones to not move

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16
Q

What do tropic molecules guide?

A

Growing axon toward a source

17
Q

What do trophic molecules do?

A

Support neurons at their final site

18
Q

Netrins interact with (blank) as chemoattracts

A

DCC

19
Q

Netrins interact with (blank) as chemorepellent

A

Unc5

20
Q

Netrins interact with extraceulluar matrix to promote?

A

Axon growth

21
Q

What happens when netrin activates DCC receptors?

A

Bring cells to midline

22
Q

When cells come to midline what happens?

A

Slit activates Robo

23
Q

What does Robo activation prevent?

A

DCC receptors from being activated

24
Q

Chemorepellant that impact brain repair following injury?

A

Molecules released by myelin in the CNS

25
Q

What does the chemo-repellent Semaphorin do?

A

activate receptors on growth cones that lead to cytoskeletal depolymerization

26
Q

What happens when Neuregulin 1 is released from presynaptic cells & activates ErbB on postsynaptic cells?

A

Promotes expression of post-synaptic proteins/receptors

27
Q

At a synapse what happens when neurexins bind neuroligins?

A

-Promote adhesion
- Help to dock synaptic vesicles & cluster post synaptic proteins
- Hypothesized that different synapses use neurligins corresponding to specific neurotransmitter

28
Q

What happens to axon or dendrites in the absence of synaptic partner?

A

Atrophy & die

29
Q

How are synapse maintained?

A

Trophic factors

Neurobiology (7 decks)

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