Consanguinity Risks and Calculations

Question 1

Coefficient of relatedness (r)

Answer 1

measures the proportion of genes that two related people have in common

r = (1/2)^n where n is the degree of relation

Question 2

Coefficient of inbreeding (F)

Answer 2

probability that a homozygote received both alleles at a locus from the same ancestral source

F = r/2

Question 3

First cousin mating risk

Answer 3

risk to have a child with a birth defect, genetic syndrome, or disability is 4-6%

Question 4

Average couple mating risk

Answer 4

risk to have a child with a birth defect, genetic syndrome, or disability is 2-3%