Connective tissues Flashcards

1
Q

What are the functions of connective tissue?

A

Structural framework, protection, supports/interconnects tissues, energy storage, transport and defense against microorganisms

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2
Q

What are the 6 cell types found in connective tissue?

A

Fibroblast, mesenchymal, adipocytes, osteoblasts and hematopoietic cells

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3
Q

What are fibroblasts?

A

They produce collagen, proteoglycans and glycoproteins

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4
Q

What are mesenchymal cells?

A

Connective tissue stem cells

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5
Q

What are adipocytes?

A

Cells that store and release fats

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6
Q

What are chondrocytes?

A

Produce and maintain cartilage components

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7
Q

What are osteoblasts?

A

Produce bone components

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8
Q

What are hematopoietic cells?

A

Produce red blood cells and immune cells

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9
Q

What is embryonic connective tissue?

A

Rich in ECM and mesenchymal cells- there is some collagen and elastic fibers

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10
Q

What types of cells are found in loose areolar CT?

A

Fixed cells like mesenchymal cells, fibroblast and adipocytes- there are also wandering cells like macrophages, mast cells, and plasma cells

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11
Q

What is the function of loose connective tissue?

A

Support and bind other tissues, hold body fluids and defense against infection

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12
Q

Where is loose connective tissue generally found?

A

underneath the membranous epithelia, blood vessels, muscles and nerves

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13
Q

What are the components of adipose CT?

A

It is composed mostly of adipocytes and very little ECM

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14
Q

What is the function of adipose CT?

A

Reserve of energy and will provide insulation against heat loss

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15
Q

Where is adipose CT generally found?

A

Under the skin, around organs in the abdomen, buttock and breast

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16
Q

What is reticular loose CT?

A

A connective tissue composed mostly of reticular fibers that functions in creating a matrix to hold free cells

17
Q

Where is reticular loose CT generally found?

A

In the liver, bone marrow, lymph nodes and spleen

18
Q

What are the components of dense irregular CT?

A

ECM is composed mostly of tightly woven collagen fibers that have no distinct pattern- Fibroblast are the primary cell type

19
Q

Where is dense irregular CT generally found?

A

in the dermis of the skin, fascia, perichondrium/periosteum and capsules that surround internal organs

20
Q

What is the dense regular CT composed of?

A

ECM is tightly compacted regularly arranged collagen fibers- fibroblast are the main cell type

21
Q

What is the function of dense regular CT?

A

Resist pulling forces

22
Q

Where is dense regular CT generally found?

A

Tendons, ligaments, aponeurosis, joint capsules and dense fascia

23
Q

What is the purpose of collagens?

A

to resist tension- most common is type 1

24
Q

What is the elastin and what is the composition?

A

A stretchable fiber that is composed of tropoelastin, fibulin-1 and fibrillins 1/2

25
What are reticular fibers?
They form a supportive meshwork
26
What are type-1 collagen fibers?
They are the most common type of collagen that are aligned/crosslinked to increase tensile strength
27
What is scurvy?
It is a vitamin C deficiency; vitamin C is a cofactor for crosslinking collagen so there will be weakened CT in the body when deficient
28
What is Elhers-Danlos syndrome?
It is a genetic disease that leads to abnormal collagen synthesis and will lead to weakened collagen fibers
29
What is Marfan's syndrome?
An autosomal dominant disorder that effects the elastin in the body. There is a mutation to the fibrillin 1 gene
30
How does Marfan's syndrome present?
It will affect the ocular, skeletal and cardiovascular systems. Pts will tend to be tall with long arms and legs
31
What is elastic CT?
High portion of elastic fibers- allow for recoil of tissue following any stretching
32
Where is CT found?
Blood vessel walls, bronchiole tubes and special ligaments
33
What are fibroblast?
They are cells found in CT that produce collagen, elastin, reticular fibers, proteoglycans and glycoproteins
34
What are adipocytes?
They are storage for fat and provide energy for the body- They are tightly packed and push their nucleus to the side
35
What are macrophages?
They perform phagocytosis and destruction of bacteria
36
What are mast cells?
They secrete chemicals like histamine that mediate the allergic reaction and heparin
37
What are plasma cells?
They differentiate from b-lymphocytes and function to produce antibodies for immunity.