Connective tissues Flashcards
Tendons connect …… to …..
It connects muscle to bone
Ligaments connects ….. to ….
It connects bone to bone
How does connective tissue vary? (3)
- Types of cells
- Abundance/density of cells
- Constitution of the ECM
What are the three types of regular connective tissue?
- Loose or areolar connective tissue
- Dense irregular connective tissue
- Dense regular connective tissue
What is the function of GAGs in the ground substance?
They are highly negatively charged and this attracts water creating a gel to which fibres and cells can embed
Ground substance is composed of ….. , ……. and …….
Glycosaminoglycans (GAGs), proteoglycans and glycoproteins
Most collagen is which type of collagen?
Type 1 collagen
Type 3 fibres are also known as ……
Reticulin
Which type of collagen is found in the basal lamina of the basement membrane?
Type IV
Which amino acid found in elastic fibres make them stretchy?
Lysine
What are the three components of elastic fibres?
Anamorphous protein, elastin and fibrillin
What is the function of fibroblasts?
To lay down collagen, elastin and reticulin
What are macrophages?
They are antigen-presenting phagocytes often found in connective tissue
Mast cells contain granules containing what?
Histamine and heparin
Areolar connective tissue is found in which four places?
Deep under the skin, the submucosa, the peritoneum and blood vessels
Reticular tissues forms lymph nodes and …….
Frameworks in the liver
Name the two main places dense regular tissue is found.
Tendons and ligaments
What type of connective tissue is found in the dermis?
Dense irregular connective tissue
How can you stain elastic fibres?
With a silver stain
What is Marfan’s syndrome?
A mutation to the fibrilin gene which affect elastic fibres. You are at risk of aortic rupture and frequent joint dislocation. Sufferers are abnormally tall and exhibit arachnodactly
What is systemic sclerosis?
It is when organs have excessive accumulation of collagen
What are the symptoms of scurvy?
Teeth falling out
Where is the nucleus positioned in brown adipose tissue?
Centrally
Ehlers- Danlos disease is a deficiency in…..
Collagen type 3 or reticulin
