Cartilage and bone Flashcards

1
Q

The large ratio of GAGs: Type 2 collagen in cartilage serves what purpose?

A

It allows diffusion between chondrocytes and blood vessels

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2
Q

Chrondrocytes lie in ……

A

Lacunae

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3
Q

What are the three types of cartilage?

A

Hyaline, elastic and fibrocartilage

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4
Q

What is the function of chondrocytes?

A

They produce and maintain the extensive extracellular matrix

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5
Q

Cartilage is surrounded by …….

A

Perichondrium

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6
Q

Hyaline cartilage contains which type of collagen?

A

Type 2

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7
Q

Give a location where hyaline cartilage may be found. (4)

A
  • Respiratory passageways
  • The ends of long bones
  • The anterior ends of the ribs
  • Foetal skeleton
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8
Q

Hyaline cartilage ……… with age

A

Calcifies

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9
Q

Elastic cartilage contains which types of fibres?

A

Type 2 collagen and elastic fibres

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10
Q

Name the three locations elastic cartilage is found (3)

A
  • Auditory tubes
  • External ear
  • Epiglottis
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11
Q

Is the perichondrium present in elastic cartilage?

A

Yes

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12
Q

What types of fibres does fibrocartilage contain?

A

It contains type 2 and type 1 collagen in thick bundles

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13
Q

What are the four locations where you would find fibrocartilage?

A
  • Intervertebral discs
  • Menisci
  • Pubic symphysis
  • Portions of tendons
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14
Q

Fibrocartilage has a perichondrium. True or false?

A

False.

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15
Q

What cell types are present in fibrocartilage?

A

Fibroblasts and chondrocytes

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16
Q

Which bone type forms a network of fine bony columns of plates to combine strength with lightness?

A

Cancellous or spongy bone

17
Q

Compact bone is found where?

A

On the external surfaces of bone

18
Q

Bone is a vascular tissue. True or false?

19
Q

Which type of bone contains Haversian canals and Volkmann’s canals?

A

Compact bone

20
Q

Which type of canal lies within the centre of an osteon?

A

Haversian canal

21
Q

What are canaliculi?

A

They are tiny interconnecting tunnels that link osteocytes and osteons

22
Q

Osteocytes lie in ……..

23
Q

What fills the gaps between the trabeculae in spongy bone?

A

Bone marrow

24
Q

How do osteoclasts break down bone?

A

Using H+ ions and lysosomal enzymes

25
Why is bone marrow yellow in appearance?
Due to the presence of adipose tissue
26
65% of bone is made of ...... ........ crystals
Calcium hydroxyapatite crystals
27
What is the most common protein in bone?
Type 1 collagen
28
What is the function of osteoblasts?
They synthesise the organic components of cells, making bones. They produce the osteoid matrix.
29
What cell type is found in the lacunae cavities, making bone?
Osteocytes
30
How do bone lamellae move to resist fracture?
They slip
31
What are the four main steps of fracture repair?
1. Haematoma formation 2. Fibrocartilaginous callus formation 3. Bony callus formation 4. Bone remodelling
32
What processes (2) give rise to the formation of a bony callus of spongy bone?
Endochondral and intramembranous ossification
33
Which cells invade to form a procallus in fracture repair?
Inflammatory cells
34
The procallus is said to be rich in granulation tissue. What is granulation tissue?
Tissue rich in capillaries and fibroblast
35
Is cartilage vascular or avascular?
Avascular