Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Musculoskeletal and connective tissue disorders > Connective tissue disorders > Flashcards

Connective tissue disorders Flashcards

1
Q

What is unique about connective tissue disorders?

A

they are multi system autoimmune inflammatory diseases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what are the 5 connective tissues disorders?

A

lupus
sclerosis
sjogrens syndrome
UCTD
raynauds syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

do autoantibodies cause connective tissue disorders?

A

NO- the cause is unknown. They do show a pattern though that indicates the disease caused.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

how are CTD’s managed?

A

aim- suppress disease activity and help pain
-nsaids/analgesics
-immune modulators (hydrochlroquine and methotrexate- 1st line)
-biological modulators
-systemic steroids -prednisolone- reduce inflammation- short term only

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what is unique about lupus?

A

-interlinks all ctd’s
-can have symptoms of all ctd’s
-every possible system involved

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what ab’s are found in CTD’s?

A

ANA
Ro
La

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what CTD’s are commonly seen together?

A

rheumatoid arthritis + sjogrens syndrome
Sclerosis + raynauds syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what form of lupus does not have autoantibodies?

A

discoid lupus- affects skin and mouth (often looks like lichen planus)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what autoantibodies are found in systemic lupus?

A

ANA
Ro
La
dsDNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what symptoms can be seen in someone with systemic lupus and what systems are commonly involved?

A

butterfly rash
renal disease- major cause of death
CVD- risk of acute CVD
lung disease
raynauds
rheumatoid arthritis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what are the dental aspects of systemic lupus?

A

-chronic anaemia- oral ulceration
-bleeding tendency
-renal disease-impaired drug metabolism
-photosensitivity
-steroid and immunosuppressants increase risk of malignancy
-discoid lupus (looks like oral lichen planus)
-hydrochloroquine- oral pigmentation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what is lupus anticoagulant?

A

lupus associated with aPL ab’s and aCL ab’s

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what is the risk of lupus anticoagulant?

A

antiphospholipid ab syndrome=thrombophillic
- risk of deep vein thrombosis and pulmonary embolism without any other risk factors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what are those with lupus anticoagulants likely taking?

A

-anticoagulants- warfarin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what does sjodrens syndrome most commonly cause?

A

-dry eyes
-dry mouth

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what gland does sjogrens syndrome commonly involve?

A

salivary glands

17
Q

what are the 3 forms of sjogrens syndrome?

A

sicca syndrome- only dry mouth or dry eyes
primary- not associated with another CTD
secondary- association with another CTD e.g raynauds and RA

18
Q

is there a test for sjogrens syndrome?

A

NO- normally clinical judgement
-imaging and histopathology can be used but high level of disease needed (salivary and lacrimal gland changes can take 30 years)

19
Q

what are the dental implications of sjogrens syndrome?

A

-xerostomia- increase caries risk and oral disease
-denture retention issues
-sialosis (swelling of salivary glands)
-salivary lymphoma- due to chronic activation of lymphoid tissue

20
Q

what is systemic sclerosis?

A

causes elastic tissue to be replaced by fibrous tissues- cannot stretch/bend tissue?

21
Q

what organs does systemic sclerosis normally affect?

A

-skin
-oesophagus
-gut

22
Q

what are common symptoms of systemic sclerosis?

A

-sclerodactaly (fingers cant stretch out)
-raynauds syndrome (bv’s narrow in fingers- ischaemia/infarction)

23
Q

what are the dental aspects of systemic sclerosis?

A

-unable to open mouth wide
-limited tongue movement
-taking impressions is difficult (must think of treatment 10-15 years in advance depending on prognosis)
-associated with sjogrens syndrome
-oesophagus cant stretch-swallowing difficulties and acid reflux (dental erosion)
-cardiac and renal involvement- affect drug metabolism

24
Q

how does CTD’s affect vessels?

A

-causes inflammation in vessel walls- leading to narrowing-ischaemia

25
Q

what disease affects larger vessels?

A

giant cell arthritis

26
Q

what does giant cell arthritis cause?

A

facial pain emergency
- affects external carotid artery and retinal artery-may lead to jaw claudication and blindness

27
Q

what disease affects medium vessels?

A

Kawasaki disease

28
Q

what are the symptoms of Kawasaki disease and who does it normally affect?

A

children
-erythema of mucosa, hands and feet
-strawberry tongue
-cracked lips

may lead to coronary artery aneurysm

29
Q

what disease affects small blood vessels?

A

wegeners granulomatosis

30
Q

what are the symptoms of wegeners granulomatosis?

A

-destruction of HT’s and St’s of mouth before spreading
-red spongy tissue commonly seen in gingiva

31
Q

what are the symptoms of wegeners granulomatosis?

A

-destruction of HT’s and St’s of mouth before spreading
-red spongy tissue commonly seen in gingiva

Musculoskeletal and connective tissue disorders (9 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions