Connective Tissue Diseases Flashcards
CT are any biological tissues with an extensive matrix that do what 3 things?
- provide structure, support and defense
- transport material
- bind organs together
CT consists of what 2 things?
- cell fibers
2. ground substance
Cell fibers consist of?
- collagen
2. elastin
What 3 things make up ground substance?
- water
- fluid
- protein
6 types of CT?
- loose tissue
- fibrous tissue
- adipose tissue
- blood
- cartilage
- bone
Loose tissue is composed of _____ and _____.
collagen; elastin
2 examples of loose tissue?
- blood vessels
2. internal organs
_____ tissue = mostly collagen, few elastin
fibrous
2 examples of fibrous tissue?
- tendons
2. ligaments
Many T diseases feature abnormal _____ system activity.
immune
Is the cause of CT diseases known?
No
3 potential causes of autoimmune diseases?
- genes
- environment
- behavious
___-___% of SLE pt’s have 1st or 2nd degree relative with SLE
10-12
3 diseases in family of CT diseases that overlap and cause mixed CT disorder?
- systemic lupus erthematosus
- scleroderma
- polymyositis/dermatomyositis
SLE = a _____-_____ disease
multi-system
9 body systems affected in SLE?
- skin
- lungs
- kidney
- CNS
- circulatory system
- heart
- GI system
- muscle and joints
- oral and nasal ulcers
Highest at risk of SLE?
women during reproductive years
SLE female:male ratio?
9:1
11 criteria for SLE classification?
- malar rash
- discoid rash
- photosensitivity
- oral ulcers
- non-erosive arthritis
- pleurites or pericarditis
- renal disorder
- neurological disorder
- hematologic disorder
- immunologic disorder
- antinuclear antibody test
5 features of non-erosive arthritis?
- transient
- symmetrical
- affecting small joints
- less severe than RA
- when arthritis is present, 5-40 % of pt’s develop a non-erosive arthropathy due to ligamentous laxity and muscle contracture
8 clinical features of SLE neurologic disorder?
- seizures
- psychosis
- behaviour/personality changes, depression
- cognitive dysfunction
- stroke
- peripheral neuropathy
- chorea
- transverse myelitis
Up to ___% of pt’s with SLE develop lupus nephritis
50
__% of pt’s with SLE require kidney dialysis or transplant
10
Renal clinical features of SLE usually (symptomatic/asymptomatic)
asymptomatic
Hallmark clinical finding in regard to renal aspect of SLE?
proteinuria
_____ clinical features of SLE most frequent cause of disease-related death
renal
___-___% of pt’s w/ SLE will experience the GI clinical features of SLE.
15-75
6 clinical features of GI aspect of SLE?
- oral ulcers
- nausea
- vomiting
- pancreatitis
- hepatitis
- mesenteric vasculitis
4 other symptoms experienced with SLE?
- pain (fibromyalgia)
- severe fatigue
- memory loss
- depression
3 aspects of PT management of pt’s with SLE?
- pain management
- therapeutic exercise and PA
- pt education
3 things to educate pt’s with SLE on?
- energy conservation principles
- joint protection principles
- sun protection
Exercise has ___ adverse effect on SLE disease activity
no
Exercise can lead to (more/less) fatigue in pt’s with SLE.
less
Exercise has a _____ effect on CR capacity in pt’s with SLE.
positive
4 p’s of energy conservation principles?
- prioritize
- plan
- pace
- posture
8 joint protection principles?
- respect for pain
- balance activity and rest
- avoid repetitive activities
- use large, stronger joints for activities
- avoid staying in 1 position for a prolonged period of time
- maintain use of joints in good alignment
- maintain healthy body weight
- maintain good posture during daily activities
Exercise and PA are safe and effective treatments for people with SLE (T/F).
TRUE
3 main non-pharmalogic interventions in the management of CT disease, such as SLE?
- pain control
- PA
- pt education
