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PHTH 565 - Rheumatology > Connective Tissue Diseases > Flashcards

Connective Tissue Diseases Flashcards

1
Q

CT are any biological tissues with an extensive matrix that do what 3 things?

A
  1. provide structure, support and defense
  2. transport material
  3. bind organs together
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2
Q

CT consists of what 2 things?

A
  1. cell fibers

2. ground substance

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3
Q

Cell fibers consist of?

A
  1. collagen

2. elastin

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4
Q

What 3 things make up ground substance?

A
  1. water
  2. fluid
  3. protein
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5
Q

6 types of CT?

A
  1. loose tissue
  2. fibrous tissue
  3. adipose tissue
  4. blood
  5. cartilage
  6. bone
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6
Q

Loose tissue is composed of _____ and _____.

A

collagen; elastin

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7
Q

2 examples of loose tissue?

A
  1. blood vessels

2. internal organs

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8
Q

_____ tissue = mostly collagen, few elastin

A

fibrous

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9
Q

2 examples of fibrous tissue?

A
  1. tendons

2. ligaments

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10
Q

Many T diseases feature abnormal _____ system activity.

A

immune

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11
Q

Is the cause of CT diseases known?

A

No

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12
Q

3 potential causes of autoimmune diseases?

A
  1. genes
  2. environment
  3. behavious
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13
Q

___-___% of SLE pt’s have 1st or 2nd degree relative with SLE

A

10-12

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14
Q

3 diseases in family of CT diseases that overlap and cause mixed CT disorder?

A
  1. systemic lupus erthematosus
  2. scleroderma
  3. polymyositis/dermatomyositis
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15
Q

SLE = a _____-_____ disease

A

multi-system

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16
Q

9 body systems affected in SLE?

A
  1. skin
  2. lungs
  3. kidney
  4. CNS
  5. circulatory system
  6. heart
  7. GI system
  8. muscle and joints
  9. oral and nasal ulcers
17
Q

Highest at risk of SLE?

A

women during reproductive years

18
Q

SLE female:male ratio?

A

9:1

19
Q

11 criteria for SLE classification?

A
  1. malar rash
  2. discoid rash
  3. photosensitivity
  4. oral ulcers
  5. non-erosive arthritis
  6. pleurites or pericarditis
  7. renal disorder
  8. neurological disorder
  9. hematologic disorder
  10. immunologic disorder
    • antinuclear antibody test
20
Q

5 features of non-erosive arthritis?

A
  1. transient
  2. symmetrical
  3. affecting small joints
  4. less severe than RA
  5. when arthritis is present, 5-40 % of pt’s develop a non-erosive arthropathy due to ligamentous laxity and muscle contracture
21
Q

8 clinical features of SLE neurologic disorder?

A
  1. seizures
  2. psychosis
  3. behaviour/personality changes, depression
  4. cognitive dysfunction
  5. stroke
  6. peripheral neuropathy
  7. chorea
  8. transverse myelitis
22
Q

Up to ___% of pt’s with SLE develop lupus nephritis

A

50

23
Q

__% of pt’s with SLE require kidney dialysis or transplant

A

10

24
Q

Renal clinical features of SLE usually (symptomatic/asymptomatic)

A

asymptomatic

25
Q

Hallmark clinical finding in regard to renal aspect of SLE?

A

proteinuria

26
Q

_____ clinical features of SLE most frequent cause of disease-related death

A

renal

27
Q

___-___% of pt’s w/ SLE will experience the GI clinical features of SLE.

A

15-75

28
Q

6 clinical features of GI aspect of SLE?

A
  1. oral ulcers
  2. nausea
  3. vomiting
  4. pancreatitis
  5. hepatitis
  6. mesenteric vasculitis
29
Q

4 other symptoms experienced with SLE?

A
  1. pain (fibromyalgia)
  2. severe fatigue
  3. memory loss
  4. depression
30
Q

3 aspects of PT management of pt’s with SLE?

A
  1. pain management
  2. therapeutic exercise and PA
  3. pt education
31
Q

3 things to educate pt’s with SLE on?

A
  1. energy conservation principles
  2. joint protection principles
  3. sun protection
32
Q

Exercise has ___ adverse effect on SLE disease activity

A

no

33
Q

Exercise can lead to (more/less) fatigue in pt’s with SLE.

A

less

34
Q

Exercise has a _____ effect on CR capacity in pt’s with SLE.

A

positive

35
Q

4 p’s of energy conservation principles?

A
  1. prioritize
  2. plan
  3. pace
  4. posture
36
Q

8 joint protection principles?

A
  1. respect for pain
  2. balance activity and rest
  3. avoid repetitive activities
  4. use large, stronger joints for activities
  5. avoid staying in 1 position for a prolonged period of time
  6. maintain use of joints in good alignment
  7. maintain healthy body weight
  8. maintain good posture during daily activities
37
Q

Exercise and PA are safe and effective treatments for people with SLE (T/F).

A

TRUE

38
Q

3 main non-pharmalogic interventions in the management of CT disease, such as SLE?

A
  1. pain control
  2. PA
  3. pt education

PHTH 565 - Rheumatology (8 decks)

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